Longitudinal Alterations of Local Spontaneous Brain Activity in Parkinson’s Disease

Qiaoling Zeng1 • Xiaojun Guan1 • Jason C. F. Law Yan Lun1 • Zhujing Shen1 • Tao Guo1 • Min Xuan1 • Quanquan Gu1 • Xiaojun Xu1 • Min Chen2 • Minming Zhang1

1Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Radiology, Beijing Hospital, Beijing, China
Qiaoling Zeng and Xiaojun Guan have contributed equally to this paper.

We used resting-state fMRI to evaluate longitudinal alterations in local spontaneous brain activity in Parkinson’s disease (PD) over a 2-year period. Data were acquired from 23 PD patients at baseline and follow-up, and 27 age- and sex-matched normal controls. Regional homogeneity (ReHo) and voxel-based-morphometry (VBM) were used to identify differences in local spontaneous brain activity and grey matter volume. With disease progression, we observed a progressive decrease in ReHo in the sensorimotor cortex, default-mode network, and left cerebellum, but increased ReHo in the supplementary motor area, bilateral temporal gyrus, and hippocampus. Moreover, there was a significant positive correlation between the rates of ReHo change in the left cerebellum and the rates of change in the Unified Parkinson’s Disease Rating Scale-III scores. VBM revealed no significant differences in the grey matter volume among the three sets of acquisitions. We conclude that ReHo may be a suitable non-invasive marker of progression in PD.

Keywords: Longitudinal; Parkinson’s disease; Regional homogeneity; Functional magnetic resonance imaging


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