The sensorimotor-striatal network might be a key systems-level marker of schizophrenia. Zhang et al., by investigating both knockout of the type I receptor tyrosine kinase ErbB4 in parvalbumin interneurons in mice and first-episode, treatment-naïve patients with schizophrenia, found that disruption of specific molecular pathways in the cerebral cortex causes structural deficits in sensorimotor cortical-striatal circuits. The cover image indicates that anomalous neuregulin 1-ErbB4 signaling and GABA transmission may be an important molecular mechanisms underlying the anatomical changes in the sensorimotor-striatal network in schizophrenia. The grid and starlights indicate NRG1-ErbB4/GABA signaling and sensorimotor-striatal deficits, respectively. See pages 97–109. (Cover image provided by Prof. Tao Li)