Visuospatial malfunction is a common symptom in Alzheimer’s disease (AD). To understand how the nervous system controls the deficient visuospatial memory in AD, the underling neural circuit needs to be identified. In the cover image, the para-hippocampal gyrus (PHG) is connected with the orbitofrontal cortex (OFC) along with neuronal transmission and a 5XFAD mouse looking in the direction of its destination, suggesting that the PHG–OFC circuit explains the neuro-anatomical basis of visuospatial memory deficits in AD, thereby providing a potential predictor for its progression and a promising interventional approach for AD. See pages 831–844. (Cover image provided by Prof. Zhijun Zhang).