Volume 36, Issue 12, 2020

The animal nature to pursuit more sex and the possible fatal consequence by excessive sex must be orchestrated by negative feedback signals. In this issue, Gao et al., investigated how continuous sexual activity could kill male flies and identified feedback neuromodulatory signals that could balance reproduction and survival. The cover image shows a critical decision in the corner for flies to pursuit sex or not, and the possible fatal consequence if faces (burning into ashes during mating). See page 1429–1440. (Cover image provided by Dr. Yufeng Pan).