Volume 38, Issue 11, 2022

The choice of a female to accept or reject male courtship is a critical decision for animal reproduction. Serotonin (5-hydroxytryptamine) has been found to regulate sexual behavior in many species, but it is unclear how it functions to regulate different aspects of sexual behavior. Ma et al. revealed that serotonin signaling plays a critical positive role in modulating the receptivity of female Drosophila melanogaster. On the cover, serotonin molecules and a subset of serotoninergic neurons in the central brain serve as a bridge of magpies enable a female fly to mate with a courting male fly more easily on Chinese Valentine’s Day (also known as the Magpie Festival). See pages 1277–1291. (Cover designed by Baoxu Ma, Rencong Wang, and Li-Chuang Studio).