1 Department of Neurosurgery, Lishui Central Hospital, Lishui 323000, China 
2 Department of Neurosurgery, the Second Affiliated Hospital of Kunming Medical College, Kunming 650101, China 
3 Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University, Shanghai 200001, China

Abstract 

Objective 
To investigate the expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) in monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion. 
Methods 
The monkeys were immediately removed brain after death in operation of group A (identical temperature perfusion group) and group B (ultraprofound hypothermia perfusion group). Immunohistochemical technique was used to determine frontal cellular expression of NGF and GDNF. Statistics were analyzed by ANOVA analyses with significance level at P < 0.05. 
Results 
The expressions of NGF and GDNF in the group B were significantly higher than those in the group A (P < 0.05). 
Conclusion 
NGF and GDNF increased significantly in the monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion. It may be a protective mechanism for neuron survival and neural function recovery.

Keywords

nerve growth factor; glial cell line-derived neurotrophicfactor; ultraprofound hypothermic circulatory arrest; resuscitation; monkey brain

[SpringerLink]