Volume 38, Issue 1, January, 2022

Original Articles

Glutamatergic Neurons in the Caudal Zona Incerta Regulate Parkinsonian Motor Symptoms in Mice
Li-Xuan Li1,2 • Yu-Lan Li1,2 • Jin-Tao Wu1,2 • Ji-Zhou Song3 • Xiao-Ming Li1,2
2022,38(1):1–15   [ Abstract]   [ SpringerLink]

Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice
Shou-He Huang1 • Wei-Zhu Liu1 • Xia Qin1 • Chen-Yi Guo1 • Qing-Cheng Xiong1 • Yu Wang1 • Ping Hu2 • Bing-Xing Pan1 • Wen-Hua Zhang1
2022,38(1):16–28   [ Abstract]   [ SpringerLink]

Association of CDH11 with Autism Spectrum Disorder Revealed by Matched-gene Co-expression Analysis and Mouse Behavioral Studies
Nan Wu1 • Yue Wang2 • Jing-Yan Jia1 • Yi-Hsuan Pan1 • Xiao-Bing Yuan1,3
2022,38(1):29-46   [ Abstract]   [ SpringerLink]

Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes
Lin Yang1 • Zhenmeiyu Li1 • Guoping Liu1 • Xiaosu Li1 • Zhengang Yang1
2022, 38(1):47-68   [ Abstract]   [ SpringerLink]

Effect of Sodium Salicylate on Calcium Currents and Exocytosis in Cochlear Inner Hair Cells: Implications for Tinnitus Generation
Ting Fan1,2 • Meng-Ya Xiang1,2 • Ruo-Qiao Zhou1,2 • Wen Li1,2 • Li-Qin Wang1 • Peng-Fei Guan1,2 • Geng-Lin Li1 • Yun-Feng Wang1,2 • Jian Li3
2022, 38(1):69-80   [ Abstract]   [ SpringerLink]

β-Catenin Deletion in Regional Neural Progenitors Leads to Congenital Hydrocephalus in Mice
Lin Ma1,4,6,7 • Yanhua Du8 • Xiangjie Xu1,4,6 • Hexi Feng1,4,6 • Yi Hui1,4,6 • Nan Li1,4,6 • Guanyu Jiang4 • Xiaoqing Zhang1,2,3,5,6 • Xiaocui Li9 • Ling Liu1,4,6,7
2022,38(1):81–94   [ Abstract]   [ SpringerLink]

Letters to the Editor

Peripheral Delivery of Ganglioside GM1 Exacerbates the Pathogenesis of Alzheimer’s Disease in a Mouse Model
Chuang-Chuang Yang1 • Yuan Cheng1 • Hai-Mei Yang1 • Yang Chen1 • Yan-Jiang Wang1 • Zhi-Qiang Xu1 • Ye-Ran Wang1
2022, 38(1):95-98   [ Abstract]   [ SpringerLink]

Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy
Xiaodan Zhang1 • Xue Wen1 • Ismael Al-Ramahi2,3 • Juan Botas2,3 • Boxun Lu1 • Yuhua Fu1
2022,38(1):99-103   [ Abstract]   [ SpringerLink]

Research Highlights

Astrocyte-derived ATP: A New Etiological Factor for Autism Spectrum Disorder
Jie Li1 • Patrizia Rubini1,2 • Yong Tang1,2 • Peter Illes1,2,3
2022, 38(1):104-106   [ Abstract]   [ SpringerLink]

Rejuvenating the Immune System: Insights for Anti-Neurodegeneration Strategies
Jie Liu1,2 • Yan-Jiang Wang1,2,3
2022, 38(1):107-109   [ Abstract]   [ SpringerLink]

Distinct Recovery Process of Consciousness and Cognition After Anesthesia
Jiani Chen1 • Liang Shan1 • Ji Dai1,2,3
2022, 38(1):110-112   [ Abstract]   [ SpringerLink]

Volume 38, Issue 1, January, 2022

About the Cover

Parkinson's disease (PD) is the second most common and fastest-growing neurodegenerative disorder. In recent years, it has been recognized that neurotransmitters other than dopamine and neuronal systems outside the basal ganglia are also associated with the pathogenesis of PD. Li et al. found that glutamatergic neurons in the caudal zona incerta (ZIc) regulate parkinsonian motor symptoms through a glutamatergic monosynaptic projection to the substantia nigra pars reticulata. Interestingly, changes in the activity of ZIcVgluT2 neurons can either induce or ameliorate parkinsonian motor impairments in healthy and PD-model mice. The cover image vividly describes this bidirectional regulation pattern: the traffic light turns red when ZIcVgluT2 neurons are hyperactive and this induces bradykinesia and impairs motor coordination. By lowering this abnormal hyperactivity, the traffic light turns green to allow amelioration of the bradykinesia and impaired motor coordination in the parkinsonian state. See pages 1–16. (Cover art by Drs Lixuan Li and Xiaoming Li).