Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia
Hongtong Chen1
· Shengyu Jin2,3,4 · Mingdong Liu3,5 ·
Yifan Zhu1
· Liren Zhang6
· Cong Li1
· Peng Liu4
·
Xiaoping Tong2,3,4 · Zhongqun Zhu1
2026,42(6):1199–1217 [
Abstract] [
SpringerLink]
The Secondary Motor Cortex-External Globus Pallidus Pathway Regulates Auditory Feedback of Volitional Control
Shengtao Luo1,2,3 · Yuchen Fan1,2 · Feiyang Yu1,2 ·
Xiaopeng Zhou1,2 · Ke Hu1,2 · Hang Yi1,2 · Hui Zhou1,2 ·
Tao Li1,2 · Jiang‑Fan Chen1,2 · Liping Zhang1,2
2026,42(6):1218–1234 [
Abstract] [
SpringerLink]
The Dorsal CA2 to Ventral CA1 Circuit Contributes to Spatial and Context-Dependent Memories
Ning Li1,2 · Bingqing Zhao1
· Xiaowen Shen1
· Hua He3
· Jianxiang Zhou1
·
Jing Zhang2 · Lin Xu4 · Xiaochun Chen2 · Chun Xu1,5,6,7
2026,42(6):1235–1247 [
Abstract] [
SpringerLink]
SIGMAR1 Drives the Development of Neuropathic Pain by Promoting AMPA Receptor Membrane Trafficking Through Interacting with NPTX1 in Male Mice
Jie Ren1
· Yasi Zheng2
· Wu Yang1
· Xueli Yin1
· Guanxi Liu1
· Ting Xu3,4 ·
Jianbo Zhang5
· Wenjun Xin3,4 · Xueqin Zhang1,6 · Suyan Lin7
2026,42(6):1248–1260 [
Abstract] [
SpringerLink]
Oligodendrocyte Egr2 Mediates the Beneficial Effect of Resocialization on the Social Ability of Socially Isolated Mice
Yanli Zhang1,2 · Sijia Chen1
· Shuying Zhang1
·
Yue Li1
· Yimiao Wang1
· Min Cao1
· Yuxi Jin1
·
Ze Wang1
· Shixin Ding1,3 · Ming Xiao1
2026,42(6):1261–1278 [
Abstract] [
SpringerLink]
Neural Circuit with Top-Down Inhibitory Feedback Outperforms Optimal Bayesian Integration in Multisensory Integration
Yelin Dong1,2 · Hongzhi You3
· Yuxiu Shao1
· Yong Gu4
·
KongFatt Wong‑Lin5
· Da‑Hui Wang1
2026,42(6):1279–1294 [
Abstract] [
SpringerLink]
GluA1 C80 Peptide Impairs Short-Term Spatial Memory in Mice by Interfering with the 4.1N Binding Site
Yongfeng Li1,2 · Jinpeng Wang1,2 · Xiaoya Zhang1,2 · Junzhao Li1,2 · Kongjie Lu1,2 ·
Zhaodi Liu1,2 · Bizheng Wang1,2 · Xuewei Yang3
· Yong Zhang1,2
2026,42(6):1295–1310 [
Abstract] [
SpringerLink]
A Novel Long-range Excitatory Neural Circuit from the Magnocellular Red Nucleus to Spinal Dorsal Horn Facilitates Neuropathic Pain-like Behaviors in Male Mice
Jiali Shi1,2 · Yinfeng Yuan1
· Yuhao Luo1 · Yue Guo1
· Jiashu Lian3
· Lin Lin1
·
Danni Chen1
· Qian Wang1
· Xiumin Xue1
· Zhichao Chen1,2 · Yongjie Wang1 ·
Zhihui Huang1
2026,42(6):1311–1324 [
Abstract] [
SpringerLink]
Diverse Neuronal Activity in Barrel Cortex During Self-Grooming and Whisking in Mice
Junye Ge1,2 · Baijun Chen2
· Jinwei Xu2
· Pengfei Ren2
· Jialong Li2
· Tangna Sun3
·
Shengxi Wu2 · Ying Zang1 · Wenting Wang2
2026,42(6):1325–1336 [
Abstract] [
SpringerLink]
GABAergic Inhibition from the Nucleus Tractus Solitarius to Ventrolateral Medulla Phox2b Neurons Modulates Central Respiratory Chemoreflex and Ventilatory Homeostasis
Liuqi Shao1
· Yake Ji1
· Hongxiao Yu1
· Zixuan Cheng1
· Fanrao Kong1
· Xiaoyi Wang1
· Bingwen Zhang2
·
Yinchang Wang1
· Yimeng Song1
· Fang Yuan1
· Congrui Fu2 · Sheng Wang1,3
2026,42(6):1337–1353 [
Abstract] [
SpringerLink]
Astrocyte-Driven Modulation of Whole-Brain Functional Networks and BOLD Signals Revealed by Optogenetic-fMRI
Zhuang Liu1
· Li Wang2
· Tiangang Lou3
· Ziyue Zhao1,4 · Hongying Du5
·
Juxiang Chen6
· Hongchun Zeng1 · Jie Wang1,7 · Kun Wang3
2026,42(6):1354–1366 [
Abstract] [
SpringerLink]
Kainate Receptors in Sensory Neurons: Molecular Identity and Functional Relevance to Pain
Sofía Degiorgi1
· Juan Lerma1
2026,42(6):1367–1387 [
Abstract] [
SpringerLink]
Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders
Tingting Bo1,2,3 · Yichun Huang4
· Yong Lu2,3 · Yang Song5
·
Jiangtao Zhang6
· Jianmin Zhang6
· Heqiu Wang6
· Zheng Wang4,7
2026,42(6):1388–1400 [
Abstract] [
SpringerLink]
Pain-Affective Disorder Comorbidity in the Temporomandibular Disorders: From Mechanistic Insights to Clinical Management
Zhaoyichun Zhang1,2,3 · Shibin Yu4 · Shengxi Wu2,3 · Zuolin Jin1 ·
Ze Fan2,3,5 · Jing Huang2,3
2026,42(6):1401–1420 [
Abstract] [
SpringerLink]
Hyoscyamine Ameliorates Repetitive Behavior in NLG1 and SHANK3 Deficient-Mice
Dandan Lv1,2,4 · Ruining Liu1,2 · Xinyu Zhang1,2 ·
Siqi Peng1,2 · Wei Xie1,2 · Mingdao Mu1,3 · An Liu1,2
2026,42(6):1421–1426 [
Abstract] [
SpringerLink]
ErbB4 in the Dorsolateral Prefrontal Cortex is Required for Sensory Gating and Working Memory in Monkey
Minzhe Yang1,2,6 · Yingying Han2
· Hongfei Zhang2
·
Chaolin Ma2
· Lin Mei3,4,5 · Baoming Li1,2
2026,42(6):1427–1432 [
Abstract] [
SpringerLink]
Epigenetic Tuning of TSC: A Metabolic Master Switch for Human Neocortical Expansion
Jun‑Wei Cao1 · Yinghui Fu2
2026,42(6):1433–1436 [
Abstract] [
SpringerLink]
Beyond the Seizure Onset Zone: Fast Ripples as Anchors for Precise Neurostimulation Therapy
Shuye Ying1
· Jialu Chen2
· Xukun Fan1
· Yi Wang1
·
Fan Fei1
2026,42(6):1437–1439 [
Abstract] [
SpringerLink]
Correction to: Long-Term Monochromatic Light Exposure Does Not Alter Modular Chromatic Representation in the Visual Cortex of Rhesus Monkeys
Wenqing Zhu1,3,4 · Ye Liu2 · Xiaoxiao Chen1,3,4 · Liling Qian2
· Wei Wang2,6 ·
Leilei Zou5
· Yiliang Lu2 · Rui Liu1,3,4
2026,42(6):1440–1440 [
Abstract] [
SpringerLink]
About the Cover
Hypothermia is widely recognized for its neuroprotective effects against cerebral hypoxic-ischemic injury, yet the developing brain remains vulnerable to white matter injury (WMI) during hypothermic hypoxia-ischemia, which can disrupt neurodevelopment and lead to long-term deficits. In this issue, Chen et al. demonstrate that microglial pyroptosis and subsequent interleukin 18 release drive mature oligodendrocyte death and axonal demyelination, ultimately causing WMI. Pharmacological inhibition of pyroptosis with disulfiram (DSF) alleviates WMI and preserves neurodevelopmental integrity. The cover is conceptualized around the theme of “the limitations of hypothermia and the protective power of pharmacotherapy”. The icy cavern encapsulates the hypothermic hypoxic-ischemic environment, visually emphasizing the paradox of hypothermia: while it offers neuroprotection, it also leaves the developing brain’s white matter—specifically the myelin sheaths—vulnerable to injury. Within this frigid landscape, the human brain is adorned with purple violets, which represent neurons, each wrapped in a delicate green layer symbolizing the myelin sheath—the primary target of damage in this pathological process. The blooming violets and intact green myelin illustrate how targeting microglial pyroptosis can restore neurodevelopmental balance, turning a state of myelin injury into one of resilience. See pages 1199–1217. (Cover provided by Dr. Xiaoping Tong and Dr. Zhongqun Zhu)
