Cross-Species Social Experience Suppresses Aggression in Drosophila
Junlong Wang1,2,3,4 · Qiantao Lv1,2,3,4 · Yaokai Yang2,3,4 · Jing Ning2,3,4 ·
Jiayin Guan2,3,4 · Dandan Chen2,3,4 · Ying Zhen2,3,4 · Yi Sun1,2,3,4
2026,42(8):1691–1705 [
Abstract] [
SpringerLink]
Preventive Memantine Treatment at the Preclinical Stage in the Alzheimer’s Disease Model of the 5xFAD Mouse
Xiaohuan Gu1,2 · Shan Ping Yu1,2 · Michael Q. Jiang1,2 · Weiwei Zhong1
·
Ananth Sastry1
· Ling Wei1
2026,42(8):1706–1724 [
Abstract] [
SpringerLink]
Characteristics and Cell Lineage Tracing of Neurod1-Cre and Neurod1-iCreER Mice Targeting Cochlear Neurons
Zhiji Chen1 · Xiaoqing Zhou1 · Ting Yang1 · Xuelai Liu1 · Juhong Zhang1 ·
Menglong Feng1 · Shaojing Kuang1 · Wei Yuan1
2026,42(8):1725–1739 [
Abstract] [
SpringerLink]
Acoustic Flutter Processing in the Inferior Colliculus of Awake Marmosets: Complementary Rate Coding Modulated by Acoustic Parameters
Siyi Bai1,4 · Xinyuan Cao1
· Min Xie1
· Guanglong Sun1
·
Xiaohui Wang1,4 · Leilei Zheng1
· Xinjian Li1,3 ·
Zheng Lin1
· Lixia Gao1,2,3,4
2026,42(8):1740–1754 [
Abstract] [
SpringerLink]
Maternal Stress During Pregnancy Induces Higher Anxiety-Like Behavior in Male Mice Offspring Under Acute Stress by Upregulating CRF/CRFR1 and Driving Time-Specific Activation of the MHb-IPN Circuit
Yujie Wang1 · Jiajia Zhao1
· Yueyang Wang3
· Zhixin Du2
· Li Wang1
· Zibo Ma1
· Siyang Sun4
· Xinyang Qu5
·
Xiaohan Geng6
· Jiaming Yan1
· Liping Yang1 · Junlin Hou1
2026,42(8):1755–1770 [
Abstract] [
SpringerLink]
CNTN6 Modulates Slit-Robo Signaling in Cortical GABAergic Interneuron Migration
Yiliang Xu1,2 · Tian Zhao1,2 · Dan Zhao1,2 · Wei Zhang1
· Di Mu1
· Ailing Gui1
·
Junzhi Guo1,2 · Kazutada Watanabe3
· Zhi‑Cheng Xiao4,5 · Haihong Ye1,2
2026,42(8):1771–1788 [
Abstract] [
SpringerLink]
Neuronal and Glial YAP/TAZ in the Spinal Cord Contribute to the Development of Bone Cancer Pain in Mice
Bo Peng1,2 · Xiaqing Lin1,2 · Jiang‑Jian Hu1,2 · Huabao Liao1,2 · Cheng Li1,2 ·
Zhaoyu Li3
· Xue‑Jun Song1,2
2026,42(8):1789–1808 [
Abstract] [
SpringerLink]
Elevation of H2S Underlies Social Deficits in Environmental Factor Double-Hit Autism Model
Hongyu Ma1,2,3,4 · Qing Xu3,4 · Songqi Dong3,4 · Mengxin Guo3,4 · Hanze Liu3,4,5 ·
Taozhi Wang6
· Mengmeng Wang3,4 · Yazhou Wang3,4 · Shengxi Wu1,2,3,4
2026,42(8):1809–1824 [
Abstract] [
SpringerLink]
Hierarchical Channel System Drives Stimulus Specificity and Polymodal Encoding in A Mechano-Cold Sensory Neuron
Linhui Zhu1,2,3,4 · Huitaong Hong2,3,4 · Mengyi Qian5
· Wang Cao2,3,4 · Zirui Luo2,3,4 ·
Jianke Gong1
· Wenjuan Zou5
· Lijun Kang2,3,4
2026,42(8):1825–1835 [
Abstract] [
SpringerLink]
Fat on Fire: Disrupted Microglial Lipid Metabolism as a Driver of Anesthetic Neurotoxicity
Yu‑Jie Mou1,2 · Hai‑Yue Tu3
· Yi‑Chan Wang1,2 · Shao‑Yong Song1,2 · Hua‑Yue Liu1,2,4 ·
Dong Wang5
· Jun‑Chao Wu6
· Xiao‑Wen Meng1,2 · Zheng‑Hong Qin6,7 · Fu‑Hai Ji1,2
2026,42(8):1836–1864 [
Abstract] [
SpringerLink]
Aging-Related Changes in the Injury Response of the Peripheral Nervous System
Yue‑Yan Cen1,2 · Mu‑Yun Wang1,2 · Qin‑Xuan Song1,2 ·
Xin‑Lin Gao1,2 · Cheng Zhou3
· Chun‑Jie Li1,4 ·
Fei Liu1,2 · Yan‑Yan Zhang1,2 · Jie‑Fei Shen1,2
2026,42(8):1865–1890 [
Abstract] [
SpringerLink]
Disruptions in RNA Splicing: A Key Regulator of Cognitive Impairment in Perioperative Neurocognitive Disorders
Xu‑An Wang1
· Qing‑Ya Wu2
· Xiao‑Yu Shi3
· Xiao‑Peng Wang1
· Yan‑Yan Gao1
·
Wei‑Wei Zhang1
· Yi‑Sheng Lu4
· Dan Liu5
· Ling‑Qiang Zhu6 · Hua Zheng2
2026,42(8):1891–1906 [
Abstract] [
SpringerLink]
From Biomarkers to New Treatments for Post-Traumatic Stress Disorder
Albert H. C. Wong1,2,3 · Le Wang4
· Yuan Shen5
·
Fang Liu1,2,4,6
2026,42(8):1907–1917 [
Abstract] [
SpringerLink]
The Dopaminergic Energy Crisis of Adolescent Depression: Mitochondrial Bioenergetics Control of Nucleus Accumbens Signaling
Salvatore Nesci1
2026,42(8):1918–1922 [
Abstract] [
SpringerLink]
Decoding ZMYND11-Related Syndromic Intellectual Disability: From Epigenetic Mysteries to Therapeutic Horizons
Rui Zheng1,2 · Zi‑Qin Liu3
· Ying Shen4 ·
Xin‑Tai Wang5
2026,42(8):1923–1928 [
Abstract] [
SpringerLink]
From Immune Cells to Matchmakers: How Brain Microglia Control Reproduction
Yixun Su1 · Chenju Yi1,2
2026,42(8):1929–1932 [
Abstract] [
SpringerLink]
Muscle-Brain Crosstalk: Mitochondrial-Derived Vesicles Linking Excessive Exercise to Cognitive Decline
Jun‑Wei Cao1
· Peng Xie2
· Cheng Yang3
·
Xiaojie Zhang4
2026,42(8):1933–1936 [
Abstract] [
SpringerLink]
Mitochondrial Transfer from Glia to Neurons: A Novel Protective Mechanism Against Peripheral Neuropathy
Xiao‑Wen Meng1,2 · Yong‑Jing Gao1
2026,42(8):1937–1939 [
Abstract] [
SpringerLink]
Correction to: Life Cycle and Circadian Rhythms in Central Resident Immunity and Neuropsychiatric Pathology
Zhixin Lim1,2,3,12 · Ha Linh Nguyen1,2,3,12 · Yuanyuan Zeng4
· Qingyue Qu5
· Yan Le5
· Ming Sun1,2,3,6,12 ·
Xiaoyu Wang1,2,3,12 · Hong Zhu8,10 · Yuchen Qian6,12 · Saboor Saeed1,2,3,12 · Huaizhi Wang1,2,3,12 · Dazhong Rong2,7,12 ·
Yueming Wang2,7,12 · Xuhong Zhang1,2,3,8,9,12 · Shaohua Hu1,2,3,8,9,11,12,13
2026,42(8):1940–1940 [
Abstract] [
SpringerLink]
About the Cover
How does past social experience shape future behavior? In this issue, Wang et al. reveal how cross-species encounters serve as a natural peacemaker for Drosophila. This adaptive behavior is dynamic: prolonged cross-species experience enhances suppression of aggression, while social isolation reverses it. The artwork illustrates a male D. melanogaster on a contested food patch alongside a closely related D. simulans and a distantly related D. virilis. Glowing elements highlight the integration of multisensory cues that persistently tune down aggression across different timescales. Flies detect non-volatile cues such as 7-T (yellow) through leg-mediated gustation to enable rapid behavioral shifts, while processing volatile pheromones such as cVA (purple) via antennal olfaction for slower modulation. Deep within the head of D. melanogaster, a body-brain circuit integrates multisensory inputs into P1 neurons, which act as a leaky integrator to record cross-species interactions and dampen the urge to fight. The artwork captures an elegant evolutionary strategy: dialing back unnecessary aggression to conserve vital energy. See pages 1691–1705. (Cover designed by Junlong Wang and Yi Sun)
