1 Department of Physiology, 2 Laboratory of Experimental Neurology, 3 Department of Pathology Anatomy, Federal University of São Paulo, São Paulo CEP 04023-900, Brazil

Abstract 

Sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Additionally, potential pathomechanisms for SUDEP is unknown, but it is very probable that cardiac arrhythmia during and between seizures, electrolyte disturbances, arrhythmogenic drugs or transmission of epileptic activity via the autonomic nervous system to the heart may play a potential role. Quite interestingly, clinical and experimental data have shown that physical activity can decrease seizure frequency, as well as lead to improved cardiovascular health in patients with epilepsy. Based on these facts, the purpose of this article is to review the body of literature of the possible contribution of physical exercise to the SUDEP prevention in a comprehensive manner.

Keywords

sudden unexpected death in epilepsy; physical activity; epilepsy; heart; seizure

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