1 Department of Mental Health, Sir Run Run Shaw Hospital, Zhejiang University Medical School, Hangzhou 310016 
2 Department of Diagnostics, Affiliated Hospital, Hangzhou Normal University Medical School, Hangzhou 310015 
3 Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University Medical School, Hangzhou 310016

Abstract 

Neuroinflammation has always been of concern in the pathogenesis of Alzheimer’s disease (AD). As a major inflammatory mediator, prostaglandin E2 (PGE2) plays an important role in the inflammatory process of AD. Up to now, there is still controversy on the neuroprotective or neurotoxic role of PGE2. However, the role of PGE2 in neurodegeneration may be far more complex, due to the 4 EP receptor subtypes. This article aims to summarize the relationship between PGE2 receptor EP subtypes and AD. It is believed that a better understanding of the PGE2 receptor EP subtypes may help to clarify the relation between inflammation and AD, and to develop novel therapeutic strategies targeting specific EP receptor for AD treatment.

Keywords

inflammation; Alzheimer’s disease; prostaglandin E2; prostaglandin E2 receptors

[SpringerLink]