1 Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China 
2 Department of Neurology at the First Affiliated Hospital of Soochow University, Suzhou 215006, China 
3 Department of Forensic Medicine, Public Security Bureau of Laoting county, Laoting 063600, China

Abstract 

Objective
The present study aimed to estimate the association between susceptibility to migraine and the 12-nucleotide insertion/deletion (indel) polymorphism in promoter region of α2B-adrenergic receptor gene (ADRA2B).
Methods
A case-control study was carried out in Chinese Han population, including 368 cases of migraine and 517 controls. Genomic DNA was extracted from blood samples, and DNA fragments containing the site of polymorphism were amplified by PCR. Data were adjusted for sex, age, migraine history and family history, and analyzed using a logistic regression model.
Results
There was no association between indel polymorphism and migraine, at either the allele or the genotype level.
Conclusion
These findings do not support a functional significance of ADRA2B indel polymorphism at position -4825 relative to the start codon in the far upstream region of the promoter in the present migraine subjects.

Keywords

migraine; promoter of α2B-adrenergic receptor gene; insertion/deletion polymorphism; genetic association

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