1 Department of Neurology, People’s Hospital of Putuo District, Shanghai 200060, China 
2 Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China 
3 Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Abstract 

Objective
The present retrospective study was to explore the clinical value of Six-Item Screener (SIS), which is constituted by 6 items from mini-mental status examination (MMSE), to identify cognitive impairment.
Methods
A total number of 1976 patients aged over 50 years, from the Memory Clinic of Huashan Hospital were employed in a battery of neuropsychological tests including MMSE. Subjects with severe conditions, unable to cooperate, or having been previously enrolled, were excluded from this study. The employed subjects were divided into 3 groups: subjective memory complaints (SMCs) (475 cases), patients with mild cognitive impairment (MCI) (440 cases), and patients with Alzheimer’s disease (AD) (1061 cases, including 555 mild, 339 moderate, and 167 severe). A total score of MMSE and a score of SIS composed of date, month, year, three-word delayed recall from MMSE were calculated. Data were analyzed based on educational background.
Results
The cut-off of SIS score was ≤2 for illiterate, ≤3 for elementary, and ≤4 for junior high school or above. The sensitivity and specificity of SIS for detecting mild AD were 88.5% and 78.3%, respectively, with an overall accuracy of 83.8%, while for detecting MCI, the sensitivity and specificity were 34.3% and 90.1%, respectively, with an overall accuracy of 63.2%.
Conclusion
SIS is an effective and reliable instrument for dementia detection in outpatient department. However, it has limited value for MCI identification.

Keywords

cognitive impairment; dementia; Six-Item Screener; mini-mental status examination

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