1 Department of Pediatrics, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China
2 Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China

Abstract 

Objective
To investigate the accuracy of amplitude-integrated electroencephalography (aEEG) in detecting full-term neonatal seizures.
Methods
Conventional EEG (cEEG) and aEEG were simultaneously applied to 62 full-term newborns with seizures and Results were analyzed with different Methods
Results
Of 876 seizures confirmed by cEEG, 21% were detected by clinical observation, 44.4% by aEEG and 85.7% by aEEG plus C3/C4 raw EEG. Of 531 seizures with a frequency higher than 5 times/h, 52.5% were detected by aEEG and 96.8% by aEEG plus C3/C4 raw EEG. Of 510 seizures lasting longer than 60 s, 50.6% were diagnosed by aEEG and 84.1% by aEEG plus C3/C4 raw EEG. Of 509 seizures originating in the central region, 57.9% were detected by aEEG and 90.9% by aEEG plus C3/C4 raw EEG.
Conclusion
Combination of aEEG with cEEG offers more accurate diagnosis, especially for detecting high-frequency, long-lasting and central region-generated seizures.

Keywords

electroencephalography; cerebral function monitoring; amplitude-integrated electroencephalography

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