1Beijing Obstetrics & Gynecology Hospital, Capital Medical University, Beijing 100026, China
2State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China
3The High School affi liated to Renmin University of China, Beijing 100080, China

Abstract 

MicroRNA alterations have been reported in patients with Alzheimer’s disease (AD) and AD mouse models. We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The increased miR-206 downregulates the expression of brain-derived neurotrophic factor (BDNF). BDNF is neuroprotective against cell death after various insults, but in embryonic and newborn APP/PS1 mice it is decreased. Thus, a specific microRNA alteration may contribute to AD pathology by downregulating BDNF.

Keywords

miR-206; brain-derived neurotrophic factor; APP/PS1; cell death; Alzheimer’s disease

[SpringerLink]