Grey matter volume abnormalities in patients with bipolar I depressive disorder and unipolar depressive disorder: a voxelbased morphometry study
1Mental Health Institute of the Second Xiangya Hospital, National Technology Institute of Psychiatry Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha 410011, China
2Department of Radiology, the Second Xiangya Hospital of Central South University, Changsha 410011, China
3Department of Mental Health and Psychiatry, Brain Hospital of Hunan Province, Changsha 410007, China
4Hunan University of Chinese Medicine Clinical Medical College, Changsha 410007, China
5Guangzhou Psychiatric Hospital, Affi liated Hospital of Guangzhou Medical College, Guangzhou 510370, China
6Key Laboratory of Arrhythmias, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai 200092, China
7Shenzhen Kangning Hospital of Guangdong Province, Shenzhen 518003, China
Corresponding author: Lingjiang Li. E-mail: llj2920@163.com
Abstract
Bipolar disorder and unipolar depressive disorder (UD) may be different in brain structure. In the present study, we performed voxel-based morphometry (VBM) to quantify the grey matter volumes in 23 patients with bipolar I depressive disorder (BP1) and 23 patients with UD, and 23 age-, gender-, and educationmatched healthy controls (HCs) using magnetic resonance imaging. We found that compared with the HC and UD groups, the BP1 group showed reduced grey matter volumes in the right inferior frontal gyrus and middle cingulate gyrus, while the UD group showed reduced volume in the right inferior frontal gyrus compared to HCs. In addition, correlation analyses revealed that the grey matter volumes of these regions were negatively correlated with the Hamilton depression rating scores. Taken together, the results of our study suggest that decreased grey matter volume of the right inferior frontal gyrus is a common abnormality in BP1 and UD, and decreased grey matter volume in the right middle cingulate gyrus may be specifi c to BP1.
Keywords
bipolar depressive disorder; unipolar depressive disorder; prefrontal cortex; cingulate gyrus; voxel-based morphometry
