An Overview of Genome-Wide Association Studies in Alzheimer’s Disease
1Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, China
2Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100053, China
3Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, China
4Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing 100053, China
Abstract
Genome-wide association studies (GWASs) have revealed a plethora of putative susceptibility genes for Alzheimer’s disease (AD). With the sole exception of the APOE gene, these AD susceptibility genes have not been unequivocally validated in independent studies. No single novel functional risk genetic variant has been identified. In this review, we evaluate recent GWASs of AD, and discuss their significance, limitations, and challenges in the investigation of the genetic spectrum of AD.
Keywords
Association analysis; Alzheimer’s disease susceptibility genes; Apolipoprotein E; Common variant
