1Institute of Neuroscience, Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China
2State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering and the Collaborative Innovation Center for Brain Science, Zhejiang University, Hangzhou 310027, China

Abstract 

As the control center of organisms, the brain remains little understood due to its complexity. Taking advantage of imaging methods, scientists have found an accessible approach to unraveling the mystery of neuroscience. Among these methods, optical imaging techniques are widely used due to their high molecular specificity and single-molecule sensitivity. Here, we overview several optical imaging techniques in neuroscience of recent years, including brain clearing, the micro-optical sectioning tomography system, and deep tissue imaging.

Keywords

Brain imaging, Tissue clearing, MOST, Optical microscopy, Deep tissue imaging

[SpringerLink]