1Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy
2CNR Institute for Microelectronics and Microsystems, Via Monteroni (Campus Ecotekne), 73100 Lecce, Italy
3Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, Lecce, Italy
4Neuropathology Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
5Department of Mathematics and Physics, University of Salento, Via Arnesano, 73100 Lecce, Italy
6CNR Institute of Nanoscience NEST, Piazza San Silvestro 12, 56127 Pisa, Italy
7Department of Regenerative Medicine, Rinaldi Fontani Institute, Viale Belfiore 43, 50144 Florence, Italy
8Research Department, Rinaldi Fontani Foundation, Viale Belfiore 43, 50144 Florence, Italy
9IRF (Shanghai) Medical Sciences, 3000 Long Dong Avenue, Zhangjiang High-Tech Park, Shanghai, China

Abstract 

In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.

Keywords

Parkinson’s disease; Neurodegeneration; Neuroinflammation; REAC TO-RGN-N treatment

[SpringerLink]