1Neuroscience Research Institute, Peking University, Beijing 100083, China
2Key Laboratory for Neuroscience, Ministry of Education of China, Peking University, Beijing 100083, China
3Key Laboratory for Neuroscience, National Committee of Health and Family Planning of China, Peking University, Beijing 100083, China
4Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100083, China
5Central Laboratory, Research Center for Translational Medicine, Department of Scientific Research, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China
6Division of Maternal and Child Health, School of Public Health, Peking University Health Science Center, Beijing 100083, China
7Wuxi Shenpingxintai Medical Technology Co., Ltd., Wuxi 214000, China

Abstract 

Autism spectrum disorder can be differentiated into three subtypes (aloof, passive, and active-but-odd) based on social behaviors according to the Wing Subgroups Questionnaire (WSQ). However, the correlations between the scores on some individual items and the total score are poor. In the present study, we translated the WSQ into Chinese, modified it, validated it in autistic and typically-developing Chinese children, and renamed it the Beijing Autism Subtyping Questionnaire (BASQ). Our results demonstrated that the BASQ had improved validity and reliability, and differentiated autistic children into these three subtypes more precisely. We noted that the autistic symptoms tended to be severe in the aloof, moderate in the passive, and mild in the active-but-odd subtypes. The modified questionnaire may facilitate etiological studies and the selection of therapeutic regimes.

Keywords

Autism spectrum disorder; Subtypes; Wing Subgroups Questionnaire; Beijing Autism Subtyping Questionnaire

[SpringerLink]