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(2019 CLARIVATE ANALYTICS)


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Volume 36, Issue. 4, April, 2020


Original Articles

Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats
Pan Gu • Zi-Hao Xu• Yu-Ze Cao • Sheng-Hui Liao • Qian-Fang Deng • Xian-Zhen Yin • Zhuo-Lu Wang • Zhuo-Hui Chen • Xin-Hang Hu • Hui Wang • Li-Zhi Li• Shi-Xin Liu• Hui Ding • Shu-Peng Shi • Hong-Lei Li• Ti-Qiao Xiao • Bo Xiao • Meng-Qi Zhang
2020, 36(4): 333-345   [ Abstract]   [ SpringerLink]   [PDF]

Homeobox B8 Targets Sterile Alpha Motif Domain-Containing Protein 9 and Drives Glioma Progression
Wenping Ma • Hongze Jin • Wenjie Liu• Xiaojuan Li • Xingang Zhou • Xinwu Guo • Runfa Tian • Qi Cui • Junjie Luo• Yueying Jiao • Youtao Yu • Haifeng Yang • Hongshan Zhao
2020, 36(4): 359-371   [ Abstract]   [ SpringerLink]   [PDF]

Epidural Spinal Cord Stimulation Promotes Motor Functional Recovery by Enhancing Oligodendrocyte Survival and Differentiation and by Protecting Myelin after Spinal Cord Injury in Rats
Gang Li • Zhong-Kai Fan • Guang-Fei Gu • Zhi-Qiang Jia • Qiang-Qiang Zhang • Jun-Yu Dai• Shi-Sheng He
2020, 36(4): 372-384   [ Abstract]   [ SpringerLink]   [PDF]

Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension
Qing Yang• Xiao-Jing Yu • Qing Su • Qiu-Yue Yi • Xin-Ai Song • Xiao-Lian Shi• Hong-Bao Li • Jie Qi • Guo-Qing Zhu • Yu-Ming Kang
2020, 36(4): 385-395   [ Abstract]   [ SpringerLink]   [PDF]

Contribution of Baroreflex Afferent Pathway to NPY-Mediated Regulation of Blood Pressure in Rats
Yang Liu • Shu-Yang Zhao • Yan Feng • Jie Sun • Xiao-Long Lu • Qiu-Xin Yan • Ying Li • Zhuo Liu • Lu-Qi Wang • Xun Sun • Shijun Li • Guo-Fen Qiao • Bai-Yan Li
2020, 36(4): 396-406   [ Abstract]   [ SpringerLink]   [PDF]

DPP-4 Inhibitor Linagliptin is Neuroprotective in Hyperglycemic Mice with Stroke via the AKT/mTOR Pathway and Anti-apoptotic Effects
Gang Zhang • Samuel Kim • Xiaohuan Gu • Shan Ping Yu • Ling Wei
2020, 36(4): 407-418   [ Abstract]   [ SpringerLink]   [PDF]

Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice
Xianjun Chen • Fei Wang • Jingli Gan• Zhonghua Zhang • Xuejun Liang• Tao Li • Nanxin Huang • Xiaofeng Zhao • Feng Mei• Lan Xiao
2020, 36(4): 419-426   [ Abstract]   [ SpringerLink]   [PDF]

Letters to the Editor

Topological Shape Changes Weaken the Innate Defensive Response to Visual Threat in Mice
Yan Huang • Lei Li • Kun Dong • Hongsi Tang • Qingning Yang • Xianglian Jia • Yundan Liao • Wenbo Wang • Zhen Ren • Lin Chen • Liping Wang
2020, 36(4): 427-432   [ Abstract]   [ SpringerLink]   [PDF]

Reviews

Orexin Receptor Antagonists as Emerging Treatments for Psychiatric Disorders
Ying Han • Kai Yuan • Yongbo Zheng • Lin Lu
2020, 36(4): 432-448   [ Abstract]   [ SpringerLink]   [PDF]

Research Highlights

Sleep Disturbance: An Early Sign of Alzheimer’s Disease
Chao He• Zhian Hu• Chenggang Jiang
2020, 36(4): 449-451   [ Abstract]   [ SpringerLink]   [PDF]


Number 4 / April

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The morphological alterations of microvessels under both normal and seizure conditions might be essential for investigating the pathogenesis and development of epilepsy. Xiao and Zhang et al., by firstly applying synchrotron radiation-based X-ray in-line phase-contrast imaging and quantitative 3-D characterization without any contrast-enhancing agents to discover 3-D hippocampal microvascular remodeling alongside the progression of epilepsy, found that the number of microvessels was markedly increased on days 1 and 14, but decreased on day 60 after seizures. The surface area, diameter distribution, mean tortuosity, and number of bifurcations and network segments also showed similar trends. The cover image indicates the 3-D angioarchitecture of the hippocampus. Continuous pseudo-color changes are used to depict the distribution spectrum of vessel diameters, ranging from 10 μm to 100 μm. See pages 333–345. (Cover image provided by Prof. Bo Xiao and Mengqi Zhang).