KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice
Hao-Ran Wang • Su-Wan Hu • Song Zhang • Yu Song • Xiao-Yi Wang • Lei Wang • Yang-Yang Li • Yu-Mei Yu • He Liu • Di Liu • Hai-Lei Ding • Jun-Li Cao
2021, 37(5): 597-610 [
Abstract] [
SpringerLink]
[PDF]
Polymodal Functionality of C. elegans OLL Neurons in Mechanosensation and Thermosensation
Yuedan Fan • Wenjuan Zou • Jia Liu • Umar Al-Sheikh • Hankui Cheng • Duo Duan • Du Chen • Siyan Liu • Luyi Chen • Jilei Xu • Firdosh Ruhomutally • Lijun Kang
2021, 37(5): 611-622 [
Abstract] [
SpringerLink]
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Projections from D2 Neurons in Different Subregions of Nucleus Accumbens Shell to Ventral Pallidum Play Distinct Roles in Reward and Aversion
Yun Yao • Ge Gao • Kai Liu • Xin Shi • Mingxiu Cheng • Yan Xiong • Sen Song
2021, 37(5): 623-640 [
Abstract] [
SpringerLink]
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Paraventricular Nucleus P2X7 Receptors Aggravate Acute Myocardial Infarction Injury via ROS-Induced Vasopressin-V1b Activation in Rats
Wenjing Cheng • Yinggang Sun • Qin Wu • Kokwin Ooi • Yi Feng • Chunmei Xia • Danian Zhu
2021, 37(5): 641-656 [
Abstract] [
SpringerLink]
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Glucose Protects Cochlear Hair Cells Against Oxidative Stress and Attenuates Noise-Induced Hearing Loss in Mice
Hao Xiong • Lan Lai • Yongyi Ye • Yiqing Zheng
2021, 37(5): 657-668 [
Abstract] [
SpringerLink]
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A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats
Yize Li • Linlin Zhang • Jing Li • Chunyan Wang • Yi Chen • Yuan Yuan • Keliang Xie • Guolin Wang • Yonghao Yu
2021, 37(5): 669-683 [
Abstract] [
SpringerLink]
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Locus Coeruleus Acid-Sensing Ion Channels Modulate Sleep–Wakefulness and State Transition from NREM to REM Sleep in the Rat
Fayaz A. Mir • Sushil K. Jha
2021, 37(5): 684-700 [
Abstract] [
SpringerLink]
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HSV-1 H129-Derived Anterograde Neural Circuit Tracers: Improvements, Production, and Applications
Hong Yang • Feng Xiong • Yi-Ge Song • Hai-Fei Jiang • Hai-Bin Qin • Jing Zhou • Sha Lu • Steven F. Grieco • Xiangmin Xu • Wen-Bo Zeng • Fei Zhao • Min-Hua Luo
2021, 37(5): 701-719 [
Abstract] [
SpringerLink]
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High-frequency Noise-induced Hearing Loss Disrupts Functional Connectivity in Non-auditory Areas with Cognitive Disturbances
Ying Luan • Richard Salvi • Lijie Liu • Chunqiang Lu • Yun Jiao • Tianyu Tang • Haiqing Liu • Gao-Jun Teng
2021, 37(5): 720-724 [
Abstract] [
SpringerLink]
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Propofol Protects Regulatory T Cells, Suppresses Neurotoxic Astrogliosis, and Potentiates Neurological Recovery After Ischemic Stroke
Yuzhu Wang • Dan Tian • Yushang Zhao • Mengyao Qu • Yuhualei Pan • Changwei Wei • Yanbing Zhu • Anshi Wu
2021, 37(5): 725-728 [
Abstract] [
SpringerLink]
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Amygdala-based Functional Network Reveals Dissociated Neural Correlates of Consensual and Idiosyncratic Emotional Movie Experiences
Lin Cui • Bingbing Guo • Dan Zhao • Jiaxin Li • Yu Luo • Ming Meng
2021, 37(5): 729-734 [
Abstract] [
SpringerLink]
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Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives
Ti-Fei Yuan • Yi Dong • Li Zhang • Jieyu Qi • Chun Yao • Yongjun Wang • Renjie Chai • Yan Liu • Kwok-Fai So
2021, 37(5): 735-745 [
Abstract] [
SpringerLink]
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Sequencing-Based High-Throughput Neuroanatomy: From Mapseq to Bricseq and Beyond
Xiaoyang Wu • Qi Zhang • Ling Gong • Miao He
2021, 37(5): 746-760 [
Abstract] [
SpringerLink]
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Alpha-Synuclein Handling by Microglia: Activating, Combating, and Worsening
Ning Song • Leilei Chen • Junxia Xie
2021, 37(5): 751-753 [
Abstract] [
SpringerLink]
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A Neural Circuit for Gut-Induced Sugar Preference
Xin Cao • Hai-Yan Yin • Henning Ulrich • Alexey Semyanov • Yong Tang
2021, 37(5): 754-756 [
Abstract] [
SpringerLink]
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Degeneration Versus Development: Hunting-Out the D-Unit of Huntington’s Disease
Shengyi Lu • Boxun Lu
2021, 37(5): 757-760 [
Abstract] [
SpringerLink]
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The mesolimbic reward system regulates nociception. In this issue, by combining circuit-specific electrophysiological recording with chemogenetic modulation, Wang et al. demonstrate distinct changes in the firing activity of two VTA dopaminergic subpopulations during chronic pain, resulting from the alterations of KCNQ channels-mediated M-currents. Furthermore, reversal of the altered activity and M-currents in the VTA-to-NAc, but not the VTA-to-mPFC dopaminergic neurons relieves thermal hyperalgesia. The mouse in the cover image, suffering from thermal pain, is trying to escape from the fire beneath the platform. The decreased function of KCNQ channels in the VTA-to-NAc circuit (red) contributes to the behavioral response to nociception in mice. See pages 597–610. (Cover image provided by Su-Wan Hu and Jun-Li Cao).
