Mapping Domain- and Age-Specific Functional Brain Activity for Children’s Cognitive and Affective Development
Lei Hao1,2,3 • Lei Li4 • Menglu Chen1,3 • Jiahua Xu1,3 • Min Jiang1,3 • Yanpei Wang1,3 • Linhua Jiang4 • Xu Chen5,6 • Jiang Qiu5,6 • Shuping Tan7 • Jia-Hong Gao8 • Yong He1,3 • Sha Tao1 • Qi Dong1 • Shaozheng Qin1,3
1 State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China
2 College of Teacher Education, Southwest University, Chongqing 400715, China
3 Key Laboratory of Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing 100875, China
4 School of Information Engineering, Huzhou University, Huzhou 313000, China
5 Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China
6 Faculty of Psychology, Southwest University, Chongqing 400715, China
7 Beijing HuiLongGuan Hospital, Peking University, Beijing 100096, China
8 Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
Abstract
The human brain undergoes rapid development during childhood, with significant improvement in a wide spectrum of cognitive and affective functions. Mapping domain- and age-specific brain activity patterns has important implications for characterizing the development of children’s cognitive and affective functions. The current mainstay of brain templates is primarily derived from structural magnetic resonance imaging (MRI), and thus is not ideal for mapping children’s cognitive and affective brain development. By integrating task-dependent functional MRI data from a large sample of 250 children (aged 7 to 12) across multiple domains and the latest easy-to-use and transparent preprocessing workflow, we here created a set of age-specific brain functional activity maps across four domains: attention, executive function, emotion, and risky decision-making. Moreover, we developed a toolbox named Developmental Brain Functional Activity maps across multiple domains that enables researchers to visualize and download domain- and age-specific brain activity maps for various needs. This toolbox and maps have been released on the Neuroimaging Informatics Tools and Resources Clearinghouse website (http://www.nitrc.org/projects/dbfa). Our study provides domain- and age-specific brain activity maps for future developmental neuroimaging studies in both healthy and clinical populations.
Keywords
Brain activity maps; FMRI; Cognition; Emotion; Reward; Development
