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Current Issue Table of Contents:15 September 2021 Volume 37, Issue 9


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Volume 37, Issue 9., September, 2021


Original Articles

Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype
Hao Li • Shihao Wu • Xia Ma • Xiao Li • Tianlin Cheng • Zhifang Chen • Jing Wu1 • Longbao Lv • Ling Li6 • Liqi Xu • Wenchao Wang1 • Yingzhou Hu • Haisong Jiang • Yong Yin • Zilong Qiu • Xintian Hu
2021, 37(9):1271-1288   [ Abstract]   [ SpringerLink]   [PDF]

Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons
Wei Lin • Wen-Wen Zhang • Ning Lyu • Hong Cao • Wen-Dong Xu • Yu-Qiu Zhang
2021, 37(9):1289-1302   [ Abstract]   [ SpringerLink]   [PDF]

The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction
Qian Wang • Ying Kong • Song Lin • Ding-Yu Wu • Jian Hu • Lang Huang • Wen-Si Zang • Xiao-Wen Li • Jian-Ming Yang • Tian-Ming Gao
2021, 37(9):1303-1313   [ Abstract]   [ SpringerLink]   [PDF]

Pinocembrin Promotes OPC Differentiation and Remyelination via the mTOR Signaling Pathway
Qi Shao • Ming Zhao • Wenwen Pei • Yingyan Pu • Mingdong Liu • Weili Liu • Zhongwang Yu • Kefu Chen • Hong Liu • Benqiang Deng • Li Cao
2021, 37(9):1314-1324   [ Abstract]   [ SpringerLink]   [PDF]

Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice
Xinyi Zhou • Bifeng Wu • Wenhao Liu • Qian Xiao • Wei He • Ying Zhou • Pengfei Wei • Xu Zhang • Yue Liu • Jie Wang • Jufang He • Zhigang Zhang • Weidong Li • Liping Wang • Jie Tu
2021, 37(9):1325-1338   [ Abstract]   [ SpringerLink]   [PDF]

Letters to the Editor

Lateral Habenula Serves as a Potential Therapeutic Target for Neuropathic Pain
Yu Du • Yu-Xing Wu • Fang Guo • Feng-Hui Qu • Ting-Ting Hu • Bei Tan • Yi Wang • Wei-Wei Hu • Zhong Chen • Shi-Hong Zhang
2021, 37(9):1339-1344   [ Abstract]   [ SpringerLink]   [PDF]

Descending Modulation of Spinal Itch Transmission by Primary Somatosensory Cortex
Zi-Han Wu • Han-Yu Shao • Yuan-Yuan Fu • Xiao-Bo Wu • De-Li Cao • Sheng-Xiang Yan • Wei-Lin Sha • Yong-Jing Gao • Zhi-Jun Zhang
2021, 37(9):1345-1350   [ Abstract]   [ SpringerLink]   [PDF]

Resolution of Inflammatory Pain by Endogenous Chemerin and G Protein-Coupled Receptor ChemR23
Ya-Kai Xie • Hao Luo • Xiao-Yun Qiu • Zhen-Zhong Xu
2021, 37(9):1351-1356   [ Abstract]   [ SpringerLink]   [PDF]

A Frameshift Variant in the SEMA6B Gene Causes Global Developmental Delay and Febrile Seizures
Li Shu • Yuchen Xu • Qi Tian • Yuanyuan Chen • Yaqin Wang • Hui Xi • Hua Wang • Neng Xiao • Xiao Mao
2021,37(9):1357-1380   [ Abstract]   [ SpringerLink]   [PDF]

Insights

Residual Recurrence Risk of Ischemic Cerebrovascular Events: Elements and Implications
Jiejie Li • Zixiao Li • Tian-jie Lyu • Si Cheng • Yuehua Pu • Yongjun Wang
2021, 37(9):1361-1364   [ Abstract]   [ SpringerLink]   [PDF]

Magnetic Resonance Imaging-Guided and Navigated Individualized Repetitive Transcranial Magnetic Stimulation for Cognitive Impairment in Schizophrenia
Xu-Sha Wu • Tian-Cai Yan • Xian-Yang Wang • Yang Cao • Xiao-Fan Liu • Yu-Fei Fu • Lin Wu • Yin-Chuan Jin • Hong Yin • Long-Biao Cui
2021, 37(9):1365-1369   [ Abstract]   [ SpringerLink]   [PDF]

Research Highlights

An Evolved Human-specific Epigenetic Mechanism for Cortical Expansion and Gyrification
Dan Li • Yunli Xie
2021, 37(9):1370-1372   [ Abstract]   [ SpringerLink]   [PDF]

Targeting the Transnitrosylation Cascade Provides a Novel Therapeutic Strategy for Alzheimer’s Disease
Yi Liu • Gang Wu • Xiji Shu • Xiaochuan Wang
2021, 37(9):1373-1376   [ Abstract]   [ SpringerLink]   [PDF]

Vasopressin Signaling Buffers Synaptic Metaplasticity in a Sex-specific Manner
Luodan Yang • Lorelei Tucker • Quanguang Zhang
2021. 37(9):1377-1380   [ Abstract]   [ SpringerLink]   [PDF]


Volume 37, Issue 9, September, 2021

Li et al. used adeno-associated virus (AAV)-delivered CRISPR/Cas9 to co-edit PINK1 and DJ-1 genes in the substantia nigra of adult rhesus monkeys, and these monkeys displayed clinical symptoms of  Parkinson's disease (PD; bradykinesia, tremor, and postural instability) and pathological hallmarks: a severe loss of nigral dopaminergic neurons (more than 60%) and phosphorylated alpha-synuclein   aggregates. Therefore, the first gene-edited monkey model of PD has been successfully developed and it will provide an important platform for investigating the etiology of PD, early biomarker  discovery, and the development of effective intervention. This modeling process is just like the Chinese fairy tale: turning a stone into gold by touching it (点石成金). In the cover image, the old immortal and shining magic arts indicate that the AAV-delivered CRISPR/Cas9 technic can turn a normal monkey into a PD monkey. See pages 1271–1288. (Cover art by Dr. Hao Li and Dr. Xintian Hu)