Focal-type, but not Diffuse-type, Amyloid Beta Plaques are Correlated with Alzheimer’s Neuropathology, Cognitive Dysfunction, and Neuroinflammation in the Human Hippocampus
Fan Liu1,2 · Jianru Sun2
· Xue Wang1,2 · Sixuan Jin2
· Fengrun Sun2 · Tao Wang2
· Bo Yuan2 ·Wenying Qiu1,2 · Chao Ma1,2,3
2022, 38(10):1125–1138 [
Abstract] [
SpringerLink]
[PDF]
Excitatory Crossmodal Input to a Widespread Population of Primary Sensory Cortical Neurons
Yuan-Jie Xiao1 • Lidan Wang1 • Yu-Zhang Liu1,3 • Jiayu Chen1 • Haoyu Zhang1 •
Yan Gao1 • Hua He2 • Zheng Zhao1 • Zhiru Wang1
2022, 38(10):1139–1152 [
Abstract] [
SpringerLink]
[PDF]
cPKCγ Deficiency Exacerbates Autophagy Impairment and Hyperphosphorylated Tau Buildup through the AMPK/mTOR Pathway in Mice with Type 1 Diabetes Mellitus
Jiayin Zheng1 • Yue Wang2,3 • Yue Liu1 • Song Han1 • Ying Zhang1 •
Yanlin Luo1 • Yi Yan1 • Junfa Li1 • Li Zhao1
2022, 38(10):1153–1169 [
Abstract] [
SpringerLink]
[PDF]
Altered Motor Performance, Sleep EEG, and Parkinson’s Disease Pathology Induced by Chronic Sleep Deprivation in Lrrk2G2019S Mice
Xinyao Liu1 • Hang Yu2 • Yuanyuan Wang1 • Song Li1 • Cheng Cheng1 • Murad Al-Nusaif1 • Weidong Le1,2
2022, 38(10):1170–1182 [
Abstract] [
SpringerLink]
[PDF]
Modulation of Neuronal Activity and Saccades at Theta Rhythm During Visual Search in Non-human Primates
Jin Xie1,2 • Ting Yan1 • Jie Zhang1,2,3 • Zhengyu Ma3 • Huihui Zhou1,3
2022, 38(10):1183–1198 [
Abstract] [
SpringerLink]
[PDF]
Histones of Neutrophil Extracellular Traps Induce CD11b Expression in Brain Pericytes Via Dectin-1 after Traumatic Brain Injury
Yang‑Wuyue Liu1 · Jingyu Zhang2 · Wanda Bi1,5 · Mi Zhou1 · Jiabo Li1 · Tiantian Xiong1 · Nan Yang3
· Li Zhao4 ·Xing Chen3
· Yuanguo Zhou3 · Wenhui He1 · Teng Yang1· Hao Wang2· Lunshan Xu2 · Shuang‑Shuang Dai1
2022, 38(10):1199–1214 [
Abstract] [
SpringerLink]
[PDF]
Reading-related Brain Function Restored to Normal After Articulation Training in Patients with Cleft Lip and Palate: An fMRI Study
Liwei Sun1,2,3 · Wenjing Zhang4· Mengyue Wang5 · Songjian Wang6,7,8 · Zhen Li9 · Cui Zhao1,2,3 · Meng Lin10 ·Qian Si1,2,3 · Xia Li1
· Ying Liang1,2,3 · Jing Wei1,2,3 · Xu Zhang1,2,3 · Renji Chen4 · Chunlin Li1,2,3
2022, 38(10):1215–1228 [
Abstract] [
SpringerLink]
[PDF]
Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke
Rui Mao1 • Ningning Zong1 • Yujie Hu1 • Ying Chen1 • Yun Xu1,2,3,4,5
2022, 38(10):1229–1247 [
Abstract] [
SpringerLink]
[PDF]
Role of RAGE in the Pathogenesis of Neurological Disorders
Judyta Juranek1 • Konark Mukherjee2 • Bernard Kordas1 • Michał Załe˛cki3 •
Agnieszka Korytko1 • Kamila Zglejc-Waszak1 • Jarosław Szuszkiewicz4 •
Marta Banach5
2022, 38(10):1248–1262 [
Abstract] [
SpringerLink]
[PDF]
Targeting 5-HT as a Potential Treatment for Social Deficits in Autism
Guangyi Yang1,2 • Hongyan Geng1,2 • Chun Hu1,2
2022, 38(10):1263–1266 [
Abstract] [
SpringerLink]
[PDF]
Calcium Homeostasis in Parkinson’s Disease: From Pathology to Treatment
Jingxian Zhang1 · Qingqing Shen1 · Yue Ma1 · Lin Liu1
·Wenting Jia1 · Leilei Chen1
· Junxia Xie1
2022, 38(10):1267–1270 [
Abstract] [
SpringerLink]
[PDF]
Insula and the Immune System: More than mere Co-existence?
Panagiotis Kerezoudis1 · Charles L. Howe2 · Long‑Jun Wu2 · Brian N. Lundstrom2 · Jamie J. Van Gompel1
2022, 38(10):1271–1273 [
Abstract] [
SpringerLink]
[PDF]
Microglia-Mediated Aβ Propagation in Alzheimer’s Disease
Luoman Yang1 · Shu Feng3
· Chongyun Wu3 · Luodan Yang2
2022, 38(10):1274–1276 [
Abstract] [
SpringerLink]
[PDF]
Amyloid-β (Aβ) plaques are one of the hallmarks of Alzheimer’s disease (AD). In this issue, Liu et al. investigate the correlations between AD-related brain pathology and cognitive dysfunction based on postmortem samples from the National Human Brain Bank for Development and Function. In the cover image, the left panel shows a schematic of typical diffuse-type Aβ plaques in an aging human brain with healthy neurites and normal cognition, while the right panel shows focal-type Aβ plaques with dystrophic neurites in an AD brain with cognitive impairment. The focal-type Aβ plaques infiltrated by activated, hyperplastic microglia may play a role in neural degeneration (inflamed/deformed neurons) and memory loss (discolored/fragmented family pictures) in AD patients. See pages 1125−1138. (Cover image provided by Prof. Chao Ma and Dr. Penghao Liu)
