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Current Issue Table of Contents:Volume 39, Issue 2, February, 2023


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Volume 39, Issue 2., February, 2023


Original Articles

Mechanosensitive Ion Channel TMEM63A Gangs Up with Local Macrophages to Modulate Chronic Post-amputation Pain
Shaofeng Pu1 • Yiyang Wu1 • Fang Tong2 • Wan‑Jie Du2 • Shuai Liu2 • Huan Yang2 • Chen Zhang2 • Bin Zhou2 • Ziyue Chen2 • Xiaomeng Zhou2 • Qingjian Han2 • Dongping Du1
2023,39(2):177–193   [ Abstract]   [ SpringerLink]   [PDF]

miR-34b-3p Inhibition of eIF4E Causes Post-stroke Depression in Adult Mice
Xiao Ke1,2 • Manfei Deng1,2 • Zhuoze Wu3 • Hongyan Yu1,2 • Dian Yu1,2 • Hao Li1,2 • Youming Lu2,4 • Kai Shu5 • Lei Pei1,2
2023,39(2):194–212   [ Abstract]   [ SpringerLink]   [PDF]

Spatiotemporal Dynamics of the Molecular Expression Pattern
Leilei Gong1 • Yun Gu1 • Xiaoxiao Han1 • Chengcheng Luan1 • Chang Liu1 • Xinghui Wang1 • Yufeng Sun1 • Mengru Zheng1 • Mengya Fang1 • Shuhai Yang1 • Lai Xu1 • Hualin Sun1 • Bin Yu1 • Xiaosong Gu1 • Songlin Zhou1
2023,39(2):213–244   [ Abstract]   [ SpringerLink]   [PDF]

Somatostatin-Positive Neurons in the Rostral Zona Incerta Modulate Innate Fear-Induced Defensive Response in Mice
Shan Lin1,2 · Meng‑Yue Zhu1,2 · Meng‑Yu Tang1,2 · Mi Wang1,2 · Xiao‑Dan Yu1,2 · Yi Zhu1,2 · Shi‑Ze Xie1,2 · Dan Yang1 · Jiadong Chen1,2 · Xiao‑Ming Li1,2,3
2023,39(2):245–260   [ Abstract]   [ SpringerLink]   [PDF]

Elevated Levels of Naturally-Occurring Autoantibodies Against the Extracellular Domain of p75NTR Aggravate the Pathology of Alzheimer's Disease
Chen‑Yang He1,8 · Ding‑Yuan Tian1,5 · Si‑Han Chen1,6 · Wang‑Sheng Jin1,3 · Yuan Cheng1 · Jia‑Yan Xin1,7 · Wei‑Wei Li1,8 · Gui‑Hua Zeng1,3 · Cheng‑Rong Tan1,3 · Jie‑Ming Jian1 · Dong‑Yu Fan1,9 · Jun‑Rong Ren1 · Yu‑Hui Liu1,3 · Yan‑Jiang Wang1,2,3,4 · Fan Zeng1,3
2023,39(2):261–272   [ Abstract]   [ SpringerLink]   [PDF]

Extension of the Lifespan of a Mouse Model of Rett Syndrome by Intracerebroventricular Delivery of MECP2
Kan Yang1 · Cheng Cheng2 · Yiting Yuan1 · Yuefang Zhang1 · Shifang Shan1 · Zilong Qiu1,3
2023,39(2):297–302   [ Abstract]   [ SpringerLink]   [PDF]

MAGED4B Promotes Glioma Progression via Inactivation of the TNF-α-induced Apoptotic Pathway by Down-regulating TRIM27 Expression
Can Liu1,2 · Jun Liu2,3 · Juntang Shao2,3 · Cheng Huang4 · Xingliang
2023,39(2):273–291   [ Abstract]   [ SpringerLink]   [PDF]

Letters to the Editor

Connectivity Map of Subthalamic Corticotropin-releasing Hormone Neurons in the Mouse Brain
Yu‑Ting Tseng1 · Lisha Liang1,2 · Binghao Zhao1 · Jialin Ye1,2 · Liping Wang1
2023,39(2):292–296   [ Abstract]   [ SpringerLink]   [PDF]

Extension of the Lifespan of a Mouse Model of Rett Syndrome by Intracerebroventricular Delivery of MECP2
Kan Yang1 · Cheng Cheng2 · Yiting Yuan1 · Yuefang Zhang1 · Shifang Shan1 · Zilong Qiu1,3
2023,39(2):297–302   [ Abstract]   [ SpringerLink]   [PDF]

Reviews

Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions
Menglong Jin1,2 · Shi‑Qing Cai1
2023,39(2):303–314   [ Abstract]   [ SpringerLink]   [PDF]

Neural Correlates of Spatial Navigation in Primate Hippocampus
Dun Mao1,2
2023,39(2):315–327   [ Abstract]   [ SpringerLink]   [PDF]

Brain Systems Underlying Fundamental Motivations of Human Social Conformity
Xinling Chen1,2,3,4 · Jiaxi Liu1,2,3,4 · Yue‑Jia Luo5,6,7,8 · Chunliang Feng1,2,3,4
2023,39(2):328–342   [ Abstract]   [ SpringerLink]   [PDF]

Insights

Potential Effects of the COVID-19 Pandemic on the Developing Brain
Xiang Yu1,2,3 · Xiu Xu4
2023,39(2):343–347   [ Abstract]   [ SpringerLink]   [PDF]

Brain-Computer Interfaces in Disorders of Consciousness
Qiheng He1,4 • Jianghong He1 • Yi Yang1,2,3,4 • Jizong Zhao1,4
2023,39(2):348–352   [ Abstract]   [ SpringerLink]   [PDF]

Research Highlights

Stereopure AIMer: A Promising RNA Base-editing Tool for Monogenic Neurological Diseases
Jingyu Yu1 · Tianwen Li1 · Kezhu Chen1 · Qisheng Tang1 · Jianhong Zhu1
2023,39(2):353–355   [ Abstract]   [ SpringerLink]   [PDF]

PROK2–PROKR2 Signaling: New Contributor to Pleasant Touch
Feng‑Lin Chen1 · Hai‑Yan Yin1,2 · Yong Tang1,2,3
2023,39(2):356–358   [ Abstract]   [ SpringerLink]   [PDF]

Infusion of Cerebrospinal Fluid from Young Mice Reverses Memory Loss in Aged Mice
Luodan Yang1 · Quanguang Zhang1
2023,39(2):359–361   [ Abstract]   [ SpringerLink]   [PDF]

Charting Normative Brain Variability Across the Human Lifespan
Yongbin Wei1 · Han Zhang1 · Yong Liu1
2023,39(2):362–364   [ Abstract]   [ SpringerLink]   [PDF]


Volume 39, Issue 2, February 2023

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Chronic post-amputation pain (CPAP), including stump pain and phantom pain, causes great suffering to amputees, but the mechanism is still elusive. Pu et al. found that the stump neuroma plays an essential role in CPAP. Specifically, the nociceptors express the mechanosensitive ion channel TMEM63A and macrophages infiltrate into the dorsal root ganglia then work synergistically to promote CPAP. In the cover image, two post-amputation mice are standing on the Tai Chi diagram composed of Yin and Yang. The mouse standing on the Yin has more TMEM63A channels and macrophage infiltration is experiencing pain and weeping, while the mouse standing on the Yang has fewer TMEM63A channels and macrophages is free of pain and dancing happily. See pages 177–193. (Cover designed by Drs Shaofeng Pu and Fan Li).