Novel Mechanism, Drug Target and Therapy in Epilepsy
Cenglin Xu1 · Yi Wang1 · Zhong Chen1
2024,40(5):561–563 [
Abstract] [
SpringerLink]
[PDF]
Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy
Yujia Shen1,2 · Yiwei Gong1,2 · Xiaoli Da1
· Shajing Gao1
· Shuo Zhang1,4 · Minjuan Sun1
· Yuanzhi Yang1
·
Xiaoyun Qiu1
· Menghan Li1
· Yang Zheng1,3 · Fan Fei1,2 · Yi Wang1,2 · Zhong Chen1,2 · Cenglin Xu1
2024,40(5):564–576 [
Abstract] [
SpringerLink]
[PDF]
Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats
Jing‑Jing Yang1,2,3 · Ying‑Xin Liu1,3 · Yan‑Fang Wang1,3 · Bi‑Ying Ge3
· Ying Wang2
· Qing‑Shan Wang3,4 ·
Sheng Li1,3 · Jian‑Jie Zhang1,2 · Ling‑Ling Jin3
· Jau‑Shyong Hong5
· Sheng‑Ming Yin1,3 · Jie Zhao1,3
2024,40(5):577–593 [
Abstract] [
SpringerLink]
[PDF]
Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil
Peng‑Peng Wu1,2 · Bi‑Rong Cao1,2 · Fu‑Yun Tian1,3 ·
Zhao‑Bing Gao1,2,3
2024,40(5):594–608 [
Abstract] [
SpringerLink]
[PDF]
Pathological and Physiological High-frequency Oscillations on Electroencephalography in Patients with Epilepsy
Hongyi Ye1 · Cong Chen1
· Shennan A. Weiss2,3,4 ·
Shuang Wang1
2024,40(5):609–620 [
Abstract] [
SpringerLink]
[PDF]
The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy
Xiuxiu Liu1,2 · Ying Zhang1,2 · Yanming Zhao1,2 ·
Qian Zhang1,2 · Feng Han1,2,3,4
2024,40(5):621–634 [
Abstract] [
SpringerLink]
[PDF]
Interleukins in Epilepsy: Friend or Foe
Yuan Dong1 · Xia Zhang1
· Ying Wang1,2
2024,40(5):635–657 [
Abstract] [
SpringerLink]
[PDF]
The Contributions of Thrombospondin-1 to Epilepsy Formation
Yao Cheng1
· Yujie Zhai1
· Yi Yuan1
· Qiaoyun Wang1
·
Shucui Li1
· Hongliu Sun1
2024,40(5):658–672 [
Abstract] [
SpringerLink]
[PDF]
Stem Cell Transplantation Represents a New Strategy for the Treatment of Epilepsy
Yuan Zhou1
· Yi Wang1,2 · Lin Yang1
2024,40(5):673–676 [
Abstract] [
SpringerLink]
[PDF]
mTORC2: The “Ace in the Hole” for a Broader Control of Epileptic Seizures?
Shuo Zhang1
· Xiongfeng Guo2
· Wei Huang1
·
Cenglin Xu1,2
2024,40(5):677–679 [
Abstract] [
SpringerLink]
[PDF]
GABAergic Interneuron Cell Therapy for Drug-Resistant Epilepsy
Junzi Chen1
· Zhongxia Li1
· Yi Wang1
· Liying Chen2
2024,40(5):680–682 [
Abstract] [
SpringerLink]
[PDF]
Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the primary focus. It emerges as one of the most intractable situations in temporal lobe epilepsy and lacks an effective preventive strategy. Shen et al. demonstrate that electrical low-frequency stimulation at the hippocampal subiculum could successfully prevent extensive secondary epileptogenesis by interfering with the synaptic connection enhancement between the primary focus and secondary focus. In a scenario shown on the cover, the seahorse (represents the hippocampal subiculum region) holds the hammerhead shark (represents the enhanced synaptic connections) with a lightening chain (represents the electrical low-frequency stimulation), and slowing down the process of secondary epileptogenesis. See pages 564–576. (Cover designed and provided by Yiwei Gong, Cenglin Xu, and Zhong Chen)
