Single-Nucleus Transcriptomics of the Nucleus Accumbens Reveals Cell-Type-Specific Dysregulation in Adolescent Macaques with Depressive-Like Behaviors
Teng Teng1,2 · Qingyuan Wu1,3 · Bangmin Yin1,2 · Jushuang Zhang2
· Xuemei Li1,2 ·
Lige Zhang2
· Xinyu Zhou1,2 · Peng Xie1
2025,41(7):1127–1144 [
Abstract] [
SpringerLink]
[PDF]
Oligodendrocyte Precursor Cell-Specific HMGB1 Knockout Reduces Immune Cell Infiltration and Demyelination in Experimental Autoimmune Encephalomyelitis Models
Gyuree Kim1,2 · JiHye Seo1,2 · Bokyung Kim1,2,3 · Young‑Ho Park4
· Hong Jun Lee5,6 ·
Fuzheng Guo7,8 · Dong‑Seok Lee1,2
2025,41(7):1145–1160 [
Abstract] [
SpringerLink]
[PDF]
The 5-HT Descending Facilitation System Contributes to the Disinhibition of Spinal PKCγ Neurons and Neuropathic Allodynia via 5-HT2C Receptors
Xiao Zhang1,2 · Xiao‑Lan He1
· Zhen‑Hua Jiang1,3 · Jing Qi1
· Chen‑Chen Huang1
·
Jian‑Shuai Zhao1
· Nan Gu1
· Yan Lu1
· Qun Wang1
2025,41(7):1161–1180 [
Abstract] [
SpringerLink]
[PDF]
Interleukin-33 Knockout Promotes High Mobility Group Box 1 Release from Astrocytes by Acetylation Mediated by P300/CBP-Associated Factor in Experimental Autoimmune Encephalomyelitis
Yifan Xiao1,2,3 · Liyan Hao1,2,3 · Xinyi Cao1,3 · Yibo Zhang1,3 · Qingqing Xu1,3 · Luyao Qin1,3 · Yixuan Zhang1,3 ·
Yangxingzi Wu1,3 · Hongyan Zhou1,2,3 · Mengjuan Wu1,2,3 · Mingshan Pi1,3 · Qi Xiong1,3 · Youhua Yang1,3 ·
Yuran Gui1,3 · Wei Liu1,2,3 · Fang Zheng4,5 · Xiji Shu1,2,3 · Yiyuan Xia1,2,3
2025,41(7):1181–1197 [
Abstract] [
SpringerLink]
[PDF]
A Personalized Predictor of Motor Imagery Ability Based on Multi-frequency EEG Features
Mengfan Li1 · Qi Zhao1
· Tengyu Zhang2 ·
Jiahao Ge1
· Jingyu Wang1
· Guizhi Xu3
2025,41(7):1198–1212 [
Abstract] [
SpringerLink]
[PDF]
Triangular Wave tACS Improves Working Memory Performance by Enhancing Brain Activity in the Early Stage of Encoding
Jianxu Zhang1 · Jian Ouyang2
· Tiantian Liu2
· Xinyue Wang2
· Binbin Gao3
· Jinyan Zhang1
· Manli Luo4
·
Anshun Kang2
· Zilong Yan1
· Li Wang2 · Guangying Pei2
· Shintaro Funahashi5
· Jinglong Wu2
· Jian Zhang2 ·
Tianyi Yan2
2025,41(7):1213–1228 [
Abstract] [
SpringerLink]
[PDF]
Targeting 5-HT to Alleviate Dose-Limiting Neurotoxicity in Nab-Paclitaxel-Based Chemotherapy
Shuangyue Pan1,2 · Yu Cai1,2 · Ronghui Liu1,2 · Shuting Jiang1,2 · Hongyang Zhao1,2 · Jiahong Jiang2
· Zhen Lin2
·
Qian Liu2
· Hongrui Lu2
· Shuhui Liang2
· Weijiao Fan2
· Xiaochen Chen2
· Yejing Wu2
· Fangqian Wang6
·
Zheling Chen2
· Ronggui Hu4,5,7 · Liu Yang2,3
2025,41(7):1229–1245 [
Abstract] [
SpringerLink]
[PDF]
Fibrinogen-tau Aggregates Exacerbate Tau Pathology and Memory Deficits in Alzheimer’s Disease Model Mice
Tingting Wen1
· Lanxia Meng1
· Han Liu1
· Qian Zhang1
· Lijun Dai1
· Liqin Huang1
·
Liang Dan1
· Kedong Zhu1
· Jiaying Luo1
· Zhaohui Zhang1
2025,41(7):1246–1260 [
Abstract] [
SpringerLink]
[PDF]
Infrared Laser Stimulation of Purkinje Cells Primarily Depends on TRP Channel Activation
Bin‑Bin Dong1
· Chen Wang1,2 · Wan‑Qi Huang1
· Yu‑Peng Bian1
· Jun Liu2
·
Wei Chen3
· Lin Zhou3
· Ying Shen1,2,3,4 · Luxi Wang1
2025,41(7):1261–1266 [
Abstract] [
SpringerLink]
[PDF]
Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases
Xiao Cui1
· Lei Xiao1
2025,41(7):1267–1288 [
Abstract] [
SpringerLink]
[PDF]
What Information do Systemic Pathological Changes Bring to the Diagnosis and Treatment of Alzheimer’s Disease?
Jinyue Zhou1
· Xiaoli Sun2
· Keren Wang3
· Min Shen4
· Jingbo Yu1
· Qi Yao1
·
Hang Hong3
· Chunlan Tang3 · Qinwen Wang1
2025,41(7):1289–1301 [
Abstract] [
SpringerLink]
[PDF]
Psilocybin and Obsessive-Compulsive Disorder: Exploring New Therapeutic Horizons
Longwei Yang1,2 · Haohong Li3,4 · Xiaohui Wang1,2,4
2025,41(7):1302–1306 [
Abstract] [
SpringerLink]
[PDF]
Imaging and Quantifying the Diversity of Native NMDA Receptors
Sophie Shi1 · David Stroebel1 · Laetitia Mony1 ·
Pierre Paoletti1
2025,41(7):1307–1310 [
Abstract] [
SpringerLink]
[PDF]
Novel Strategies for Cognitive Enhancement via Noninvasive Neuromodulation
Hongwei Li1,2 · Kun Zhao2,3 · Yong Liu2,3,4
2025,41(7):1311–1313 [
Abstract] [
SpringerLink]
[PDF]
The Astrocyte: A New Component of The Engram Regulates Memory Recall
Ru Li1,2 · Zilan Luo1,2 · Ding Zhong2,4 · Xia Deng2
·
Liang Gao1,2,3
2025,41(7):1314–1316 [
Abstract] [
SpringerLink]
[PDF]
Adolescent depression involves complex, cell-type-specific changes in brain regions such as the nucleus accumbens (NAc). Using single-nucleus RNA sequencing, Teng et al. revealed that the stress-related gene FKBP5 is significantly upregulated in glial cells of the NAc in adolescent macaques with depressive-like behaviors. The cover illustration draws inspiration from the legendary Chinese figure “Sun Wukong (孙悟空)”, the Monkey King, to symbolize the battle against depression. Here, FKBP5 is wielded as a golden cudgel “Ruyi Jingu Bang (如意金箍棒)”, striking down a blue demon labeled “Depression” in the stormy valleys of the NAc. The heroic monkey, supported by younger peers, represents the potential of glial-targeted therapeutic strategies for adolescent depression. See pages 1127–1144. (Cover provided by Dr. Teng Teng)
