Salvianolic Acid B and Ginsenoside Rg1 Combination Attenuates Cerebral Edema Accompanying Glymphatic Modulation
Lingxiao Zhang1,2 · Yanan Shao2,3 · Zhao Fang2,3 · Siqi Chen4 · Yixuan Wang2,3 · Han Sha4 ·
Yuhan Zhang4 · Linlin Wang2 · Yi Jin5 · Hao Chen2,3 · Baohong Jiang1,2,3,4
2025,41(11):1909–1923 [
Abstract] [
SpringerLink]
Piezo1 Mediates Ultrasound-Stimulated Dopaminergic Neuron Protection via Synaptic Vesicle Recycling and Ferroptosis Inhibition
Tian Xu1 · Li Zhang2,3 · Xiaoxiao Lu4
· Wei Ji5
·
Kaidong Chen2,3
2025,41(11):1924–1938 [
Abstract] [
SpringerLink]
13-Docosenamide Enhances Oligodendrocyte Precursor Cell Differentiation via USP33-Mediated Deubiquitination of CNR1 in Chronic Cerebral Hypoperfusion
Yuhao Xu1,2,3,4,5 · Yi Tan1,2,3,4,5 · Zhi Zhang1,2,3,4,5 · Duo Chen1,2,3,4,5 · Chao Zhou1,2,3,4,5 · Liang Sun1,2,3,4,5 ·
Shengnan Xia1,2,3,4,5 · Xinyu Bao1,2,3,4,5 · Haiyan Yang1,2,3,4,5 · Yun Xu1,2,3,4,5
2025,41(11):1939–1956 [
Abstract] [
SpringerLink]
Neural Tracking of Race-Related Information During Face Perception
Chenyu Pang1
· Na Zhou1
· Yiwen Deng1
· Yue Pu1
·
Shihui Han1
2025,41(11):1957–1976 [
Abstract] [
SpringerLink]
Csde1 Mediates Neurogenesis via Post-transcriptional Regulation of the Cell Cycle
Xiangbin Jia1
· Wenqi Xie1
· Bing Du1
· Mei He1,6 · Jia Chen1,7 · Meilin Chen1
· Ge Zhang1
· Ke Wang2
·
Wanjing Xu3
· Yuxin Liao1
· Senwei Tan1
· Yongqing Lyu1
· Bin Yu1
· Zihang Zheng1
· Xiaoyue Sun1
· Yang Liao1
·
Zhengmao Hu1,4 · Ling Yuan1,4 · Jieqiong Tan1,4 · Kun Xia1,3 · Hui Guo1,5
2025,41(11):1977–1990 [
Abstract] [
SpringerLink]
Interactively Integrating Reach and Grasp Information in Macaque Premotor Cortex
Junjun Chen1,2 · Guanghao Sun1,3 · Yiwei Zhang1,3 · Weidong Chen1
·
Xiaoxiang Zheng1,3 · Shaomin Zhang1,4 · Yaoyao Hao1,3,4
2025,41(11):1991–2009 [
Abstract] [
SpringerLink]
Human Cortical Organoids with a Novel SCN2A Variant Exhibit Hyperexcitability and Differential Responses to Anti-Seizure Compounds
Yuling Yang1
· Yang Cai1
· Shuyang Wang1
· Xiaoling Wu1
· Zhicheng Shao3
·
Xin Wang1
· Jing Ding1,2
2025,41(11):2010–2024 [
Abstract] [
SpringerLink]
Suprachiasmatic Nucleus Vasoactive Intestinal Peptide Neurons Mediate Light-induced Transient Forgetting
Xiaoya Su1,2,3 · Yikai Tang1 · Yi Zhong1,2,3,4 ·
Yunlong Liu1,5
2025,41(11):2025–2035 [
Abstract] [
SpringerLink]
Pre-action Neuronal Encoding of Task Situation Uncertainty in the Medial Prefrontal Cortex of Rats
Qiulin Hua1,2 · Yu Peng2
· Jianyun Zhang2
·
Baoming Li1
· Jiyun Peng1,2
2025,41(11):2036–2048 [
Abstract] [
SpringerLink]
Dissecting Social Working Memory: Neural and Behavioral Evidence for Externally and Internally Oriented Components
Hanxi Pan1 · Zefeng Chen1 · Nan Xu1 · Bolong Wang1 · Yuzheng Hu1 · Hui Zhou1,2 · Anat Perry3 ·
Xiang‑Zhen Kong1,2 · Mowei Shen1 · Zaifeng Gao1
2025,41(11):2049–2062 [
Abstract] [
SpringerLink]
Modulation of Ryanodine Receptors on Microglial Ramification, Migration, and Phagocytosis in an Alzheimer’s Disease Mouse Model
Yulin Ouyang1,2 · Zihao Chen1
· Qiang Huang1
· Hai Zhang1
· Haolin Song1
· Xinnian Wang1
· Wenxiu Dong1
·
Yong Tang1
· Najeebullah Shah3
· Shimin Shuai3
· Yang Zhan1,4
2025,41(11):2063–2077 [
Abstract] [
SpringerLink]
Transient Formation of Stress Granules Disturbs Neural Stem Cell Differentiation
Mengmeng Wang1
· Yarong Wang1
· Hongyu Ma2,3 · Hanze Liu4
· Yating Lu5
· Yaozhong Zhang5
· Zhihui Huang5
·
Songqi Dong1
· Kun Zhang1
· Shengxi Wu1
· Yazhou Wang1
2025,41(11):2078–2082 [
Abstract] [
SpringerLink]
Diuretic Hormone 31 Regulates Sleep and Memory via Distinct Signaling Pathways in Drosophila melanogaster
Lin Yan1,2 · Litao Wu2,5 · Xin Chen2,6 ·
Xiaojuan Su2,7 · Yuantao Li1,8 · Chang Liu2,3,4
2025,41(11):2083–2088 [
Abstract] [
SpringerLink]
Restoring Retinoic Acid: Alleviating Autism-Like Behaviors in Sox5-Deficient Mice
Lanyan Lin1
· Yongxing Lai1
· Ainong Mei1
·
Yan Chen1
· Fan Lin1
2025,41(11):2089–2094 [
Abstract] [
SpringerLink]
Targeting Microglial Connexin43 Hemichannels: A Novel Therapeutic Avenue for Alzheimer’s Disease
Chenju Yi1,2,3,4 · Yixun Su1
· Alexei Verkhratsky3,5,6,7,8
2025,41(11):2095–2099 [
Abstract] [
SpringerLink]
Astrocytic Cannabinoid Receptor 1 Governs Stress Resilience by Orchestrating Blood-Brain Barrier Integrity
Xiaopeng Ding1
· Yulan Li1
2025,41(11):2100–2102 [
Abstract] [
SpringerLink]
α-Synuclein Pathology from Kidney to Brain in Parkinson’s Disease
Yihang Han1
· Yanjuan Wang1
· Yunnan Lu2
·
Chunming Xie1
· Di Wu1
2025,41(11):2103–2105 [
Abstract] [
SpringerLink]
Retraction Note: Fluoxetine is Neuroprotective in Early Brain Injury via its Anti-inflammatory and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model
Hui‑Min Hu1 · Bin Li2 · Xiao‑Dong Wang1 · Yun‑Shan Guo1 · Hua Hui1 · Hai‑Ping Zhang1 · Biao Wang1 · Da‑Geng Huang1 · Ding‑Jun Hao1
2025,41(11):2106–2106 [
Abstract] [
SpringerLink]
Retraction Note: Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats
Xinzhi Wang1
· Shuyue Li2
· Jinbang Ma1
·
Chuangang Wang1
· Anzhong Chen3
· Zhenxue Xin1
·
Jianjun Zhang1
2025,41(11):2107–2107 [
Abstract] [
SpringerLink]
About the Cover
Cerebral edema is a threatening complication of ischemic stroke. In this issue, Zhang et al. demonstrate that the combination of Salvianolic acid B and ginsenoside Rg1 (SalB/Rg1) alleviates cerebral edema related to the regulation of the glymphatic system (GS). The cover art creatively depicts this concept: At the center of the image lies the brain. On its left, a red vessel represents the cerebral artery; on its right, a blue vessel represents the cerebral vein. The perivascular spaces surrounding both arteries and veins are filled with light blue fluid, symbolizing the glymphatic system. Cerebrospinal fluid flows inward along the perivascular spaces of arteries, while interstitial fluid drains outward along the venous perivascular spaces. The unobstructed circulation of these inflow and outflow pathways is essential for maintaining normal brain function. After a stroke, however, the two pathways appear to be “tied into a knot,” triggering the onset of cerebral edema. The left hand represents Salvianolic acid B derived from Salvia miltiorrhiza, and the right hand represents Ginsenoside Rg1 derived from Panax notoginseng. Acting together like a pair of deft hands, SalB and Rg1 work to untie the knot that obstructs cerebrospinal fluid inflow and interstitial fluid outflow, thereby restoring glymphatic circulation and alleviating cerebral edema. See pages 1909–1923. (Cover provided by Huanqi Tan).
