Unbiased Segmentation and Multifeature Classification of Cortical Neuronal Activity Reveals Complex Dynamics Under Anesthesia
Zilin Wang1 · Ao Li1 · Guihua Xiao2
· Xingzheng Gu1
· Zhilei Wang1
·
Shuting Guo1 · Rujin Zhang1 · Chaowei Zhuang3
· Jiangbei Cao1
2026,42(3):491–504 [
Abstract] [
SpringerLink]
Modulation of Glutamate Release by Dexmedetomidine Preserves Dendritic Spines and Alleviates Cognitive Impairment in a Murine Model of Perioperative Neurocognitive Disorder
Yan Zhang1,2,3 · Junzhao Li4
· Xueju Wang5
· Zhongyu Zhang6
·
Shuai Long4
· Chuanyu Edward Li4
· Yan Liu7
· John Man Tak Chu3
·
Raymond Chuen‑Chung Chang8
· Gordon Tin‑Chun Wong3,9 · Yong Zhang4,10
2026,42(3):505–524 [
Abstract] [
SpringerLink]
BIN1 Interacts with Tau Fragments to Inhibit TrkB Signaling Endosome Recycling in a Mouse Model of Alzheimer’s Disease
Yanuo Wei1
· Ye Xi2
· Hui Li2
· Xingxing Zhang2
· Yu Wang2
· Yunpeng Li2
·
Ronghao Fang2
· Jie Xiang2 · Shengxi Wu1,2
2026,42(3):525–538 [
Abstract] [
SpringerLink]
Single-Nucleus Transcriptomic Sequencing Revealed Cellular and Molecular Changes in a Pilocarpine-Induced Epilepsy Rat Model
Ying Wang1 · Yue Wang2
· Fei Yu1
· Yidi Liu1
·
Xin Liu3,4 · Zhengxu Cai1
2026,42(3):539–558 [
Abstract] [
SpringerLink]
Endothelial GATAD1 Exacerbates Blood-brain Barrier Dysfunction in Ischemic Stroke through Caveolae-mediated Transcytosis
Lizhen Fan1 · Hui Liu3
· Shanshan Li1
· Lingling Li1
· Zhi Zhang2,4,5,6,7 · Pinyi Liu2,4,5,6,7 · Haiyan Yang2,4,5,6,7 ·
Shengnan Xia2,4,5,6,7 · Xiang Cao2,4,5,6,7 · Chun Wang1
· Yun Xu2,4,5,6,7
2026,42(3):559–575 [
Abstract] [
SpringerLink]
Spatially Resolved Lipid Composition of the Human Brain Cortical Layers
Dmitry Senko1 · Marina Zavolskova1
· Olga Efimova1
· Maria Osetrova1
·
Elena Stekolshchikova1
· Gleb Vladimirov1
· Evgeny Nikolaev1
· Philipp Khaitovich1
2026,42(3):576–588 [
Abstract] [
SpringerLink]
Electrophysiological Characterization of Murine Vestibular Efferent Neurons and Modulation by Acute Peripheral Vestibular Deprivation
Jinyu Wang1,2 · Mengfan Xu1,2 · Lei Zhang1,2 · Wenjie Liu1,2 · Siyue Wang1,2 ·
Liqin Wang1,2 · Ning Cong1,2 · Geng‑Lin Li1,2,3 · Jing Wang1,2
2026,42(3):589–604 [
Abstract] [
SpringerLink]
Potential Transmission of Alpha-Synuclein from the Gastrointestinal Tract to the Substantia Nigra along the Vagal Afferent Pathway
Fan Han1
· Meiqiu Liu1
· Qian Jiao1
· Xixun Du1
· Chunling Yan1
· Xi Chen1 ·
Hong Jiang1,2
2026,42(3):605–618 [
Abstract] [
SpringerLink]
Long-Term Monochromatic Light Exposure Does Not Alter Modular Chromatic Representation in the Visual Cortex of Rhesus Monkeys
Wenqing Zhu1,3,4 · Ye Liu2 · Xiaoxiao Chen1,3,4 · Liling Qian2
· Wei Wang2
·
Leilei Zou5
· Yiliang Lu2 · Rui Liu1,3,4
2026,42(3):619–629 [
Abstract] [
SpringerLink]
Mitophagy Activation by N-Acetylcysteine Protects against Mic60 Deficiency-Induced Auditory Neuropathy
Yilin Sun1
· Chunying Liu2
· Yakun Liang3
· An Lv2
· Wang Nie1
· Shuyue Bao1
· Xiaoyi Li4
· Jing Zhou4
·
Weimin Tong5,6 · Yong Tao1 · Xueling Wang4 · Tingting Dong4
2026,42(3):630–648 [
Abstract] [
SpringerLink]
Nr4a2, A Key Factor Controlling the Development and Functional Maintenance of Forebrain Car3 Neurons
Yun‑Chao Tao1 · Li Zhao1
· Qiong Zhang2
· Xi‑Yue Liu1
· Wei‑Tang Liu3
·
Ze‑Xuan Li2
· Ling Hu2 · Lei Zhang4,5 · Jia‑Yin Chen2
· Yu‑Qiang Ding1,2,3,6 ·
Ning‑Ning Song2
2026,42(3):649–662 [
Abstract] [
SpringerLink]
Emerging Roles of GluN3B NMDA Receptor Subunit in the Central Nervous System
Yuerou Huang1
· Junyi Xie2
· Jiamin Chen1
·
Siman Guo1
· Yuan Li1,2 · Fang Liu1,2,3,4,5,6,7
2026,42(3):663–678 [
Abstract] [
SpringerLink]
Genetically Modified Primate Models for Brain Disorder Research
Yi Yang1,2 · Jianbang Lin1,2 · Mengqi Li1
·
Lixin Yang1,2,3 · Zhonghua Lu1,2,3 · Ting Yan1,2,3
2026,42(3):679–696 [
Abstract] [
SpringerLink]
Lost in Space and Thought: Navigating the Cognitive Map in Alzheimer’s Disease
Bo Zhao1
· Shaojiong Zhou1
· Tao Wei1
· Jiahua Xu2
·
Chaofan Geng1
· Zhibin Wang1,3 · Yi Tang1,3,4
2026,42(3):697–711 [
Abstract] [
SpringerLink]
Persistence of Proliferating Neural Progenitors in the Adult Human Hippocampus: New Evidence from snRNA-seq and Machine Learning Integration
Jun‑Wei Cao1 · Bing Lang2
2026,42(3):712–714 [
Abstract] [
SpringerLink]
Astrocytes Control Norepinephrine Signaling in the Brain
Hai‑Yun Xiong1
· Peter Illes1,2 · Yong Tang1
2026,42(3):715–718 [
Abstract] [
SpringerLink]
Subparafascicular Thalamic Nucleus: An Integration Center for Sexual Motivation and Physical Contact in Mating Behaviour
Siyuan Li1,2 · Xinrong Wang1,5 · Junqiang Zheng1,5 ·
Han Xu1,2,3,4,5
2026,42(3):719–722 [
Abstract] [
SpringerLink]
Beyond the Glial Scar: Fibroblasts as Dynamic Coordinators of Neuroprotection and Neuroinflammation Post-Brain Injury
Xinjie Hong1,2 · Xiaoyong Qin2 · Lijun Hou1
2026,42(3):723–725 [
Abstract] [
SpringerLink]
Putting the Brakes on Thirst: A Neural Circuit for Anticipatory Fluid Control
Boli Fu1,2 · Qiujie Shi1
· Qin Wang1
2026,42(3):726–728 [
Abstract] [
SpringerLink]
About the Cover
In this issue, Wang et al. mapped cortical layer 2/3 neuronal activity across transitions between states of consciousness. Combining high-resolution wide-field calcium imaging with unbiased segmentation of population dynamics and activity-feature clustering, they show that neuronal roles are state-dependent and that neurons within the same functional group can be reassigned and switch roles across stages. The cover centers on a stylized “neural tree” to symbolize single-neuron information reception and integration. Its axon is rendered as a multicolored flowing stream, representing the activity trajectories and identity shifts of different functional groups across phases. The layered foliage in the background evokes the vastness of cortical networks and the mystery of consciousness, underscoring the limitations of our understanding of consciousness mechanisms; we “can’t see the forest for the trees”. See pages 491–504. (Cover designed by Zilin Wang)
