Glutamatergic Periaqueductal Gray Projections to the Locus Coeruleus Orchestrate Adaptive Arousal States in Threatening Contexts
Siyu Wang1,2,3,4 · Yiwen Yang1,3 · Sijia Hao5
·
Yanhui Sun3
· Hao Wang1,2,3,4
2026,42(2):255–269 [
Abstract] [
SpringerLink]
Multifaceted Role of RIMBP2 in Promoting Hearing in Murine Cochlear Hair Cells
Menghui Liao1,2,3 · Xin Chen1
· Ling Lu1
· Qing Liu1
· Rongrong Guo4,5 · Yuyang Qiu1
· Yangnan Hu1
·
Yuhua Zhang1
· Qiaojun Fang1
· Panpan Zhang1
· Yige Li1
· Shuijin He6
· Mingliang Tang5
· Huawei Li7
·
Geng‑Lin Li7
· Renjie Chai1,3,8,9,10
2026,42(2):270–284 [
Abstract] [
SpringerLink]
Preoptic Neural Circuitry for Dramatic and Gentle Thermoregulation
Ruiqi Pang1,2 · Haipeng Yu2,3 · Jincheng Wang2
· Zhiyue Shi4
· Huizhong Wen2
· Guangyan Wu5
· Xuan Zhang2
·
Yueting Zhang1,2 · Qiaoqian Wei1,2 · Bo Li6
· Xueqing Yi6
· Kai Liu6
· Shaowen Qian6
· Yi Zhou
2026,42(2):285–300 [
Abstract] [
SpringerLink]
Restoration of Extrasynaptic/Synaptic GABAAR-α5 Localization Improves Sevoflurane-Induced Early Memory Impairment in Aged Mice
Mengxue Zhang1,2,3 · Xiaokun Wang1,2,3 · Zhun Wang1,2,3 · Jinpeng Dong1,2,3 ·
Sixuan Wang1,2,3 · Ying Dong1,2,3 · Changyu Jiang4 · Yiqing Yin1,2,3
2026,42(2):301–318 [
Abstract] [
SpringerLink]
Single-Cell Sequencing Reveals Circadian Sensitivity of Noise-Induced Hearing Loss Mediated by Macrophage-Driven NLRP3 Inflammasome Activation
Qingping Ma1,2,3 · Qixuan Wang4
· Zixuan Zhu5
· Qian Zhou1,2,3 ·
Zhongying Wang1,2,3 · Minfei Qian6
· Teng Li5
· Xixi Gu5
· Zechuan Chen5
·
Xueling Wang1,3,7 · Xiaoming Zhang5
· Zhiwu Huang1,2,3,8
2026,42(2):319–337 [
Abstract] [
SpringerLink]
Cataract Aggravates Alzheimer-Like Pathologies and Cognitive Deficits in an APP/PS1 Mouse Model
Zhao Geng1,2,4,6 · Zhong‑Yuan Yu2,4 · Jun Tan6
· Xuan‑Yue Wang3
· Gui‑Hua Zeng2,4 · Jiang‑Hui Li2,4 · Yu‑Di Bai2,4 ·
Xiao‑Qin Zeng2,4 · Yu‑Peng Zhu2,4 · Cheng‑Rong Tan2,4 · An‑Yu Shi2,4 · Yu‑Hui Liu2,4 · Xian‑Le Bu2,4 · Zi Ye1 ·
Yan‑Jiang Wang2,3,4,5 · Zhao‑Hui Li1
2026,42(2):338–348 [
Abstract] [
SpringerLink]
Pou4f3 Deficiency Obstructs the Subtype Differentiation of Vestibular Hair Cells
Qin Zhou1,2 · Yikang Huang1,2 · Wenli Ni1,2 · Mingchuan Feng1,2 · Lingjie Wu1,2 ·
Chuijin Lai1,2 · Yanping Zhang1,2 · Wenyan Li1,2,3 · Yan Chen1,2
2026,42(2):349–368 [
Abstract] [
SpringerLink]
Therapeutic Potential of MgH2 in Mitigating Cisplatin-Induced Hearing Loss
Yibing Hu1,2 · Yihuan Zhang1,2 · Shufen Li3
· Yuan Yu1,2 · Jingjing Wang1,2 ·
Zihan Lou1,2 · Boya Zhang1,2 · Yazhi Xing1,2 · Zhengnong Chen1,2
2026,42(2):369–385 [
Abstract] [
SpringerLink]
Model-Dependent Attenuation of Seizures by Cinnabar
Yuang Gu1
· Yu Yao1
· Qiuwen Lou1
· Xinyan Zhu1
· Ju Lan1
· Chenshu Gao1
·
Shuangshuang Wu1
· Jingjia Liang1
· Cenglin Xu1
· Yi Wang1 · Heming Cheng1 ·
Zhong Chen1
2026,42(2):386–402 [
Abstract] [
SpringerLink]
Identification of TMED10 as A Regulator for Neuronal Exocytosis of Amyloid Beta 42
Peixin Meng1
· Longze Sha1,2 · Xiaolin Yu1
· Yanbing Wang1
· Erning Zhang1
·
Kexin Meng1
· Bingnan Li1,2 · Qin Zhao3
· Qi Xu1,2
2026,42(2):403–418 [
Abstract] [
SpringerLink]
PET Molecular Imaging of the Endocannabinoid System in Psychiatric Disorders
Chunyi Cui1,2,3,4,5 · Xiaofeng Dou2,3,4 · Peili Cen2,3,4 · Chentao Jin1,2,3,4,5 · Jing Wang1,2,3,4 · Jiaqi Niu2,3,4 ·
Chenxi Xue2,3,4 · Mei Tian6 · Hong Zhang1,2,3,4,7,8 · Yan Zhong1,2,3,4,8
2026,42(2):419–438 [
Abstract] [
SpringerLink]
Role of Microglial Dysfunction in Parkinson’s Disease: From Multifactorial Causes to Neurodegeneration
Yuxiang Xu1
· Tingting Han1
· Yue Wu2
· Haixuan Liu1
· Keyuan Hou1
· Zhaowu An1
·
Yongjie Li3
· Chaoyang Zhu1
· Song Wang2 · Jianshe Wei1
2026,42(2):439–459 [
Abstract] [
SpringerLink]
Standardized Protocol for Novel Social Defeat-Induced Specific Social Fear in Mice
Haiqin Ye1
· Hongfu Li2
· Yu Sun1
· Mengsheng Qiu1
·
Haifeng Xu2
2026,42(2):460–464 [
Abstract] [
SpringerLink]
A Medial Paralemniscal Pth2ergic Circuit Contributing to Aversive and Anxiety-Like Behaviors
Zixu Zhang1,2 · Shuyan Geng1,2 · Chuanyao Sun1,2 · Shengru Hu1,2 · Tianxiang Xu1,2 ·
Wei Xie2 · Mingdao Mu1,2
2026,42(2):465–470 [
Abstract] [
SpringerLink]
Photobiomodulation and Addiction: Exploring Mechanisms, Therapeutic Potential, and Future Directions in Substance Use Disorders
Xiujiao Qin1
· Hongyuan Li2
· Huiying Zhao1 ·
Xiaohui Wang2,3,4
2026,42(2):471–475 [
Abstract] [
SpringerLink]
IL-17 as a New Player in Neuroimmune Cross-Talk: Rewiring Behaviors Through Cytokine-Receptor Cartography
Jinmei Ye1
· Lan Yan2
· Zhibo Tang2
· Jiashuo Xu1
·
Jie Weng2 · Tifei Yuan2,3 · Daihui Peng1
2026,42(2):476–480 [
Abstract] [
SpringerLink]
Serpine2-Lrp1 and CD39-A3AR Intercellular Signalling Pathways: Novel Therapeutic Targets for Vascular Dementia
Xiao‑Feng Ran1
· Peter Illes1,2 · Yong Tang1
2026,42(2):481–484 [
Abstract] [
SpringerLink]
Beyond Amyloid: Stem Cell Therapy Targets Neurodegeneration in Alzheimer’s Disease
Chenyue Li1
· Qiyi Hu1
· Qing Wang1,2,3 ·
Chunming Xie1,2,3
2026,42(2):485–486 [
Abstract] [
SpringerLink]
The Thalamic Reticular Ultimatum: Carbamazepine’s Betrayal in Absence Epileptic Seizures
Xiongfeng Guo1
· Yuanzhi Yang1
· Junxiu Ye1
· Xiangyu Ma1
· Tong Liu1
·
Kai Zhong2 · Cenglin Xu1
2026,42(2):487–489 [
Abstract] [
SpringerLink]
Correction to: Engineered Extracellular Vesicles Loaded with MiR‑100-5p Antagonist Selectively Target the Lesioned Region to Promote Recovery from Brain Damage
Yahong Cheng1
· Chengcheng Gai1
· Yijing Zhao1
· Tingting Li1
· Yan Song1
·
Qian Luo2
· Danqing Xin1
· Zige Jiang1
· Wenqiang Chen3
· Dexiang Liu2
·
Zhen Wang1
2026,42(2):490–490 [
Abstract] [
SpringerLink]
About the Cover
The function of the locus coeruleus norepinephrine system (LC-NE) orchestrates brain-wide neural networks, influences cognitive abilities and behavioral phenotypes in specific contexts. In this issue, Wang et al. report that glutamatergic innervation from the periaqueductal gray to LC-NE gates behavioral responses—from optimal alertness to anxiety and panic—enabling adaptation to ever-changing environmental demands. The cover portrays children descending a slide that mirrors LC-NE activation dynamics—slow falls evoke anxiety, rapid descents trigger panic. This slide embodies the periaqueductal gray-to-locus coeruleus pathway, where glutamate (butterfly patterns) activates LC-NE neurons (lotus symbols), translating threat levels into adaptive arousal states. See pages 255–269. (Cover art by Xiang Ma and Shuo Wang)
