Graph Neural Networks and Multimodal DTI Features for Schizophrenia Classification: Insights from Brain Network Analysis and Gene Expression
Jingjing Gao1
· Heping Tang1
· Zhengning Wang1
· Yanling Li2
· Na Luo3,4 · Ming Song3,4 · Sangma Xie5
·
Weiyang Shi3,4 · Hao Yan6
· Lin Lu6,7 · Jun Yan6,7 · Peng Li6,7 · Yuqing Song6,7 · Jun Chen8
· Yunchun Chen9
·
Huaning Wang9
· Wenming Liu9
· Zhigang Li10 · Hua Guo10 · Ping Wan10 · Luxian Lv11,12 · Yongfeng Yang11,12 ·
Huiling Wang13 · Hongxing Zhang11,12,14 · Huawang Wu15 · Yuping Ning15 · Dai Zhang6,7,16 · Tianzi Jiang3,4,17
2025,41(6):933–950 [
Abstract] [
SpringerLink]
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression
Zhuoran Ma1
· Yan Xu1
· Piaopiao Lian1
· Yi Wu1
· Ke Liu1
· Zhaoyuan Zhang1
·
Zhicheng Tang1
· Xiaoman Yang2
· Xuebing Cao1
2025,41(6):951–969 [
Abstract] [
SpringerLink]
Fto-dependent Vdac3 m6A Modification Regulates Neuronal Ferroptosis Induced by the Post-ICH Mass Effect and Transferrin
Zhongmou Xu1,2 · Haiying Li1,2 · Xiang Li1,2 · Jinxin Lu1,2 · Chang Cao1,2 ·
Lu Peng1,2 · Lianxin Li1,2 · John Zhang3
· Gang Chen1,2
2025,41(6):970–986 [
Abstract] [
SpringerLink]
Dysregulated Pathways During Pregnancy Predict Drug Candidates in Neurodevelopmental Disorders
Huamin Yin1,2 · Zhendong Wang3
· Wenhang Wang2
· Jiaxin Liu2
· Yirui Xue4
·
Li Liu2
· Jingling Shen2 · Lian Duan1
2025,41(6):987–1002 [
Abstract] [
SpringerLink]
Cancer-Associated Fibroblasts Interact with Schwann Cells for Tumor Perineural Invasion by Oral Squamous Cell Carcinoma
Xinwen Zhang1
· Yijia He1
· Shixin Xie1
· Yuxian Song1
· Xiaofeng Huang2
·
Qingang Hu1
· Yanhong Ni1
· Yi Wang1
· Yong Fu1
· Liang Ding
2025,41(6):1003–1020 [
Abstract] [
SpringerLink]
Engineered Extracellular Vesicles Loaded with MiR-100-5p Antagonist Selectively Target the Lesioned Region to Promote Recovery from Brain Damage
Yahong Cheng1
· Chengcheng Gai1
· Yijing Zhao1
· Tingting Li1
· Yan Song1
·
Qian Luo2
· Danqing Xin1
· Zige Jiang1
· Wenqiang Chen3
· Dexiang Liu2
·
Zhen Wang1
2025,41(6):1021–1040 [
Abstract] [
SpringerLink]
Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study
Aichen Feng1,2 · Dongmei Zhi3
· Zening Fu4
· Shan Yu5
· Na Luo1
· Vince Calhoun4
·
Jing Sui3
2025,41(6):1041–1053 [
Abstract] [
SpringerLink]
How Fear Memory is Updated: From Reconsolidation to Extinction?
Jiahui Chen1
· Zhuowen Fang1
· Xiaolan Zhang2
·
Yanrong Zheng2
· Zhong Chen1,2
2025,41(6):1054–1084 [
Abstract] [
SpringerLink]
Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis
Shasha Zhang1,2 · Hairong Xiao1,2 · Yanqin Lin1,2 ·
Xujun Tang1
· Wei Tong1
· Buwei Shao9
· He Li8 ·
Lei Xu7 · Xiaoqiong Ding1 · Renjie Chai1,2,3,4,5,6
2025,41(6):1085–1102 [
Abstract] [
SpringerLink]
Perifornical UCN3 Neurons Regulate Overeating-Induced Weight Gain
Shanshan Lu1,2,3,4,5 · Xinran Zhang1
· Wanqi Chen1
· Baofang Zhang1
· Haiyang Jing1
· Yunlong Xu1,6 ·
Fengling Li1,3,4 · Chenyu Jiang7
· Gaowei Chen1,3,4 · Xiaofei Deng1,3,4,5 · Yingjie Zhu1,2,3,4,5
2025,41(6):1103–1108 [
Abstract] [
SpringerLink]
Propofol Promotes Anesthesia Through the Activation of Centrally-Projecting Edinger–Westphal Nucleus Urocortin 1-Positive Neurons
Jing Huang1 · Yiwen Hu1 · Sheng Jing1 · Fuhai Bai1 · Zonghong Long1 · Zhuoxi Wu1 · Liang Fang1 ·
Lei Cao1 · Youliang Deng1 · Xiaohang Bao1 · Hong Li1
2025,41(6):1109–1114 [
Abstract] [
SpringerLink]
A Potentially Shared Neural Basis Linking Rapid Saccades and Avoidance Initiation in the Superior Colliculus Driven by Visual Threats
Zhou Sun1 · Yu Gu1
2025,41(6):1115–1118 [
Abstract] [
SpringerLink]
Follistatin, A Novel Therapeutic Target for Chronic Pain
Huimin Nie1
· Boyi Liu1
2025,41(6):1119–1122 [
Abstract] [
SpringerLink]
Stress-Induced Endogenous Cannabinoid Signaling Contributes to Fear Generalization
Yanan Yue1,2 · Xia Zhang1
· Yuan Dong1,2
2025,41(6):1123–1126 [
Abstract] [
SpringerLink]
About the Cover
Schizophrenia, a severe psychiatric disorder, poses challenges in diagnosis due to symptom heterogeneity. In this study, Gao et al. use graph neural networks with diffusion tensor imaging (DTI) to classify schizophrenia, achieving high accuracy, and linking brain imaging markers to genetic biomarkers via interpretable analysis. The cover image depicts brain network structures and genetic interactions, symbolizing the study’s integration of neuroimaging and genomics for improved schizophrenia detection. (Cover art by Dr. Yefei Li)
