Recent Advances in Unraveling the Mechanisms of Pain and Itch: The Third Special Issue
Ru‑Rong Ji1,2,3,4
2025,41(12):2109–2112 [
Abstract] [
SpringerLink]
Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice
Meng‑Ge Li1,2 · Shu‑Ting Qu3
· Yang Yu2
·
Zhenhua Xu1
· Fu‑Chao Zhang2
· Yong‑Chang Li1,2 ·
Rong Gao1 · Guang‑Yin Xu2
2025,41(12):2113–2126 [
Abstract] [
SpringerLink]
Hippocampal Extracellular Matrix Protein Laminin β1 Regulates Neuropathic Pain and Pain-Related Cognitive Impairment
Ying‑Chun Li1,2 · Pei‑Yang Liu2,3 · Hai‑Tao Li2,4 · Shuai Wang2,5 · Yun‑Xin Shi2
· Zhen‑Zhen Li2
· Wen‑Guang Chu2
·
Xia Li2,6 · Wan‑Neng Liu2
· Xing‑Xing Zheng1,2 · Fei Wang2
· Wen‑Juan Han2
· Jie Zhang7
· Sheng‑Xi Wu2
·
Rou‑Gang Xie2
· Ceng Luo2,8
2025,41(12):2127–2147 [
Abstract] [
SpringerLink]
The Bed Nucleus of the Stria Terminalis—Paraventricular Nucleus of the Hypothalamus Neural Circuit Regulates Neuropathic Pain Through the Brain-Spleen Axis
Shoumeng Han1 · Xin Chen2 · Li Ma3 · Xin Zeng1
· Ying Wang1
· Tingting Xie3
·
Fancan Wu3
· Kun Song3
· Kenji Hashimoto4 · Hanbing Wang3
· Long Wang1
2025,41(12):2148–2166 [
Abstract] [
SpringerLink]
Sex Differences in Pain Contagion Determined by the Balance of Oxytocin and Corticosterone in the Anterior Cingulate Cortex in Rodents
Zhiyuan Xie1
· Wenxi Yuan1
· Lingbo Zhou1
· Jie Xiao1,2 · Huabao Liao1,2 ·
Jiang‑Jian Hu1,2 · Xue‑Jun Song1,2
2025,41(12):2167–2183 [
Abstract] [
SpringerLink]
Cortical Control of Itch Sensation by Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Anterior Cingulate Cortex
Yiwen Zhang1 · Jiaqi Li1 · You Wu1
· Jialin Si2
· Yuanyuan Zhu1 · Meng Nian2 · Chen Chen1 ·
Ningcan Ma1 · Xiaolin Zhang1 · Yaoyuan Zhang1
· Yiting Lin1,3 · Ling Liu3
· Yang Bai4 · Shengxi Wu1 ·
Jing Huang1
2025,41(12):2184–2200 [
Abstract] [
SpringerLink]
SOX11-mediated CBLN2 Upregulation Contributes to Neuropathic Pain through NF-κB-Driven Neuroinflammation in Dorsal Root Ganglia of Mice
Ling‑Jie Ma1
· Tian Wang1
· Ting Xie1
· Lin‑Peng Zhu1
·
Zuo‑Hao Yao1
· Meng‑Na Li1
· Bao‑Tong Yuan1
·
Xiao‑Bo Wu1
· Yong‑Jing Gao1
· Yi‑Bin Qin1
2025,41(12):2201–2217 [
Abstract] [
SpringerLink]
Fibroblast Growth Factor 8 Suppresses Neurotoxic Astrocytes and Alleviates Neuropathic Pain via Spinal FGFR3 Signaling
Huizhu Liu1 · Lanxing Yi1 · Guiling Li1
·
Kangli Wang1
· Hongsheng Wang2 · Yuqiu Zhang1 ·
Benlong Liu1
2025,41(12):2218–2232 [
Abstract] [
SpringerLink]
Downregulation of Neuralized1 in the Hippocampal CA1 Through Reducing CPEB3 Ubiquitination Mediates Synaptic Plasticity Impairment and Cognitive Deficits in Neuropathic Pain
Yan Gao1
· Yiming Qiao1
· Xueli Wang1
· Manyi Zhu1
· Lili Yu1
· Haozhuang Yuan1
·
Liren Li1
· Nengwei Hu1
· Ji‑Tian Xu1,2
2025,41(12):2233–2253 [
Abstract] [
SpringerLink]
CDK5-Induced HCN2 Channel Dysfunction in the Prelimbic Cortex Drives Allodynia and Anxiety-Like Behaviors in Neuropathic Pain
Lu Chen1
· Shuai Cao1
· Yun‑Ze Liu1
· Qi‑Fan Yang1
· Jin‑Yu Yang1
· Dan‑Yang Zhang1
· Guo‑Guang Xie1
·
Xiang‑Sha Yin1
· Ying Zhang1 · Yun Wang1,2
2025,41(12):2254–2271 [
Abstract] [
SpringerLink]
Genetic Variation A118G in the OPRM1 Gene Underlies the Dimorphic Response to Epidural Opioid-Induced Itch
Xiaomeng Zhou1
· Ai‑Lun Li1
· Wan‑Jie Du1
· Pengyu Gao1
· Bin Lai1 ·
Fang Fang1 · Qingjian Han1 · Jing Cang1
2025,41(12):2272–2284 [
Abstract] [
SpringerLink]
AQMFB-DWT: A Preprocessing Technique for Removing Blink Artifacts Before Extracting Pain-evoked Potential EEG
Wenjia Gao1
· Dan Liu1 · Qisong Wang1 ·
Yongping Zhao1
· Jinwei Sun1
2025,41(12):2285–2295 [
Abstract] [
SpringerLink]
Chemokine CCL2 Mediates Neuroglial Crosstalk and Drives Chronic Pain Pathogenesis
Junyu Lu1,2,3 · Yunxin Shi1,2,4 · Yongkang Li1,2,3 · Ziyi Niu1,2 · Shengxi Wu1,2 ·
Ceng Luo1,2 · Rou‑Gang Xie1,2
2025,41(12):2296–2321 [
Abstract] [
SpringerLink]
Senescent Nociceptors: A Novel Therapeutic Target for Chronic Pain Treatment
Shi‑Yu Sun1
· Xiu‑Hua Miao1
· Guo‑Kun Zhou1
·
Tong Liu1
2025,41(12):2322–2325 [
Abstract] [
SpringerLink]
About the Cover
The neural mechanisms of pain and itch involve intricate molecular, cellular, and circuit-level interactions that span from peripheral sensory neurons to higher cortical centers. This special issue integrates cutting-edge approaches—including gene editing, neural circuit tracing, and EEG algorithm optimization—to unravel these complexities across multiple dimensions. On the cover, the visual elements symbolize how convergent technological perspectives are essential to decode the multifaceted nature of pain and itch, ultimately paving the way for targeted therapeutic strategies. (Cover art by Dr. Yefei Li).
