Amplitude-Integrated Electroencephalography Predicts Outcome in Patients with Coma After Acute Brain Injury
Wendong You1,2 • Qilin Tang1,2 • Xiang Wu1,2 • Junfeng Feng1,2 • Qing Mao1,2 • Guoyi Gao1,2,* • Jiyao Jiang1,2
1Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
2Shanghai Institute of Head Trauma, Shanghai 200127, China
Abstract
Prognostication of coma patients after brain injury is important, yet challenging. In this study, we evaluated the predictive value of amplitude-integrated electroencephalography (aEEG) for neurological outcomes in coma patients. From January 2013 to January 2016, 128 coma patients after acute brain injury were prospectively enrolled and monitored with aEEG. The 6-month neurological outcome was evaluated using the Cerebral Performance Category Scale. aEEG monitoring commenced at a median of 7.5 days after coma onset. Continuous normal voltage predicted a good 6-month neurological outcome with a sensitivity of 93.6% and specificity of 85.2%. In contrast, continuous extremely low voltage, burst-suppression, or a flat tracing was correlated with poor 6-month neurological outcome with a sensitivity of 76.5% and specificity of 100%. In conclusion, aEEG is a promising predictor of 6-month neurological outcome for coma patients after acute brain injury.
Keywords
Amplitude-integrated electroencephalography; Coma; Acute brain injury; Outcome
