Correlation of Ferroptosis and Other Types of Cell Death in Neurodegenerative Diseases

Xiaoting Dang1 • Xuejie Huan1 • Xixun Du1 • Xi Chen1 • Mingxia Bi1 • Chunling Yan1 • Qian Jiao1 • Hong Jiang1

1 Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis, Prevention of Neurological Disorders, State Key Disciplines: Physiology, School of Basic Medicine, Qingdao University, Qingdao 266071, China



    Ferroptosis is defined as an iron-dependent, nonapoptotic cell death pathway, with specific morphological phenotypes and biochemical changes. There is a growing realization that ferroptosis has significant implications for several neurodegenerative diseases. Even though ferroptosis is different from other forms of programmed death such as apoptosis and autophagic death, they involve a number of common protein molecules. This review focuses on current research on ferroptosis and summarizes the cross-talk among ferroptosis, apoptosis, and autophagy that are implicated in neurodegenerative diseases. We hope that this information provides new ideas for understanding the mechanisms and searching for potential therapeutic approaches and prevention of neurodegenerative diseases.




    Ferroptosis; Apoptosis; Autophagic death; Neurodegenerative diseases