What Information do Systemic Pathological Changes Bring to the Diagnosis and Treatment of Alzheimer’s Disease?
Jinyue Zhou1 · Xiaoli Sun2 · Keren Wang3 · Min Shen4 · Jingbo Yu1 · Qi Yao1 · Hang Hong3 · Chunlan Tang3 · Qinwen Wang11 Health Science Center, The First Afliated Hospital, Ningbo University, Ningbo 315010, China
2 Department of Chemistry, Lishui University, Lishui 32300, China
3 Health Science Center, School of Public Health, Ningbo University, Ningbo 315211, China
4 Reference Laboratory, Medical System Biotechnology Co., Ltd, Ningbo 315104, China
Abstract
Alzheimer’s disease (AD) is regarded as a neurodegenerative disease, and it has been proposed that AD may be a systemic disease. Studies have reported associations between non-neurological diseases and AD. The correlations between AD pathology and systemic (non-neurological) pathological changes are intricate, and the mechanisms underlying these correlations and their causality are unclear. In this article, we review the association between AD and disorders of other systems. In addition, we summarize the possible mechanisms associated with AD and disorders of other systems, mainly from the perspective of AD pathology. Regarding the relationship between AD and systemic pathological changes, we aim to provide a new outlook on the early warning signs and treatment of AD, such as establishing a diagnostic and screening system based on more accessible peripheral samples.
Keywords
Alzheimer’s disease; Central nervous system; Peripheral system; Non-neurological diseases
