Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis
Shasha Zhang1,2 · Hairong Xiao1,2 · Yanqin Lin1,2 · Xujun Tang1 · Wei Tong1 · Buwei Shao9 · He Li8 · Lei Xu7 · Xiaoqiong Ding1 · Renjie Chai1,2,3,4,5,61 State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology-Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China
2 Southeast University Shenzhen Research Institute, Shenzhen 518063, China
3 Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China
4 Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing 100081, China
5 Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China
6 Institute for Stem Cells and Regeneration, Chinese Academy of Science, Beijing 100081, China
7 Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan 250022, China
8 Department of Otolaryngology, The First Afliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
9 School of Medicine, Faculty of Medical & Health Sciences, Tel Aviv University, 6997801 Tel Aviv, Israel
Abstract
Sensorineural hearing loss (SNHL), the most commonly-occurring form of hearing loss, is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea. Numerous environmental and physiological factors have been shown to cause acquired SNHL, such as ototoxic drugs, noise exposure, aging, infections, and diseases. Several programmed cell death (PCD) pathways have been reported to be involved in SNHL, especially some novel PCD pathways that have only recently been reported, such as ferroptosis, necroptosis, and pyroptosis. Here we summarize these PCD pathways and their roles and mechanisms in SNHL, aiming to provide new insights and potential therapeutic strategies for SNHL by targeting these PCD pathways.
Keywords
Sensorineural hearing loss; Programmed cell death; Ferroptosis; Necroptosis; Pyroptosis
