Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders
Tingting Bo1,2,3 · Yichun Huang4 · Yong Lu2,3 · Yang Song5 · Jiangtao Zhang6 · Jianmin Zhang6 · Heqiu Wang6 · Zheng Wang4,7
1 Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2 Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
3 Clinical Neuroscience Center, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
4 School of Psychological and Cognitive Sciences; Beijing Key Laboratory of Behavior and Mental Health; National Key Laboratory of General Artificial Intelligence; IDG/McGovern Institute for Brain Research; Peking‑Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
5 Department of Radiology, Central Hospital of Dalian University of Technology, Dalian 116033, China
6 Tongde Hospital of Zhejiang Province (Zhejiang Mental Health Center), Zhejiang Office of Mental Health, Hangzhou 310012, China
7 School of Biomedical Engineering, Hainan University, Haikou 570228, Hainan, China
Abstract
This review delves into brain imaging genomics, an interdisciplinary field merging brain imaging, genomics, and additional biomarkers with clinical data. The primary aim is to uncover new insights into the brain’s phenotypic, genetic, and molecular characteristics. We emphasize recent advances in genome-wide association studies and transcriptome-wide association studies, especially their integration with MRI-derived phenotypes in humans. These studies are crucial for understanding how various factors influence brain structure and function in normal and pathological states. Furthermore, this review highlights imaging transcriptomics progress in non-human primates, essential for elucidating brain organization and improving animal models evolutionarily to bridge gaps in understanding human disorders. We conclude that brain imaging genomics is set to transform research in neurological and psychiatric disorders, owing to its holistic approach that merges advanced genetic analysis with detailed imaging, will deepen our understanding of the brain, and usher in a new epoch in brain imaging research.
Keywords
MRI-derived phenotypes; Psychiatric diseases; Transcriptome analyses; Non-human primates
