1 International Collaborative Centre on Big Science Plan for Purine Signaling, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China

2 Acupuncture and Chronobiology Key Laboratory of Sichuan Province, Chengdu 610075, China

3 Department of Biochemistry, Institute of Chemistry, University of Sa˜o Paulo, Sa˜o Paulo 05508, Brazil

4 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia 117997

5 Rudolf-Boehm-Institut fu¨r Pharmakologie und Toxikologie, Universitaet Leipzig, 04109 Leipzig, Sachsen, Germany

Abstract 

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