Volume 37, Issue 2, 2021


Acid-sensing ion channel 1a (ASIC1a) acts as the main proton sensor, is a novel synaptic receptor, and plays critical roles in learning and memory. In this issue, Song et al. demonstrate the post-synaptic targeting and strong spatiotemporal dynamics of ASIC1a in dendrites and spines using self-designed tools. The cover image is derived from the well-known Chinese fairytale called “Monkey King Thrice Defeats the White-bone Demon (孙悟空三打白骨精)”. With his piercing eyes, Monkey King was able to distinguish monsters from ordinary human beings at the first glance. The piercing eyes represent the newly-developed tools to visualize the ASIC1a channel, and the elbow joint of the white-bone demon seen by Monkey King depicts synaptic connection, which is highlighted in the circle and illustrates the location and mobility of ASIC1a channels in excitatory synapses. See pages 145165. (Cover art by Drs Fei Dong, Jian-Fei Lu, and Xing-Lei Song).