Volume 37, Issue 6, 2021

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated demyelinating disorder characterized by widespread inflammation that damages myelin in the brain and spinal cord. Xiu et al. found that children and adolescents are more frequently affected. Although ADEM occurs predominantly in children, 59% of the patients who die of ADEM are adults. In the cover image, a young lady standing on the open book is suffering from ADEM, yet she still looks just like any other kid, wearing a smile on her face in the hope of improved care and cure. The Temple of Heaven (“Tiantan”) with a stethoscope in the background indicates that the study was carried out in Beijing Tiantan Hospital, the host of the National Clinical Research Center for Neurological Diseases. See pages 804–808. (Cover art by Dr. Fei Dong and Dr. Xin-Di Li).