Volume 37, Issue 7, 2021

Nerve agents are among the deadliest poisons known to man. In this issue, Wang et al. demonstrate the “dual-switch” function of TRPV4 in the treatment of nerve agent intoxication. TRPV4 is a key target of soman poisoning due to its modulation of NMDA-mediated excitotoxicity in the early stage of poisoning and NLRP3-medicated neuroinflammation in the late stage. As shown in this cover image, the brain is attacked by the nerve agent soman, and a defensive line formed by blocking TRPV4 and its downstream NMDAR and NLRP3 pathways can effectively protects the brain against the nerve agent. See pages 905–920. (Cover image designed by Shuai Wang).