Volume 37, Issue 9, 2021

Li et al. used adeno-associated virus (AAV)-delivered CRISPR/Cas9 to coedit PINK1 and DJ-1 genes in the substantia nigra of adult rhesus monkeys, and these monkeys displayed clinical symptoms of Parkinson’s disease (PD; bradykinesia, tremor, and postural instability) and pathological hallmarks: a severe loss of nigral dopaminergic neurons (more than 60%) and phosphorylated alpha-synuclein aggregates. Therefore, the first gene-edited monkey model of PD has been successfully developed and it will provide an important platform for investigating the etiology of PD, early biomarker discovery, and the development of effective intervention. This modeling process is just like the Chinese fairy tale: turning a stone into gold by touching it ( 点石成金 ). In the cover image, the old immortal and shining magic arts indicate that the AAV-delivered CRISPR/Cas9 technic can turn a normal monkey into a PD monkey. See pages 1271–1288. (Cover art by Dr. Hao Li and Dr. Xintian Hu)