Department of Neurology, Second Affi liated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Corresponding author: Baorong Zhang. E-mail: brzhang@zju.edu.cn

Abstract 

Recent research has shown that defined sets of exogenous factors are sufficient to convert rodent and human somatic cells directly into induced neural stem cells or neural precursor cells (iNSCs/iNPCs). The process of transdifferentiation bypasses the step of a pluripotent state and reduces the risk of tumorigenesis and genetic instability while retaining the self-renewing capacity. This iNSC/iNPC technology has fueled much excitement in regenerative medicine, as these cells can be differentiated into target cells for re placement therapy for neurodegenerative diseases. Patients’ somatic cell-derived iNSCs/iNPCs have also been proposed to serve as disease models with potential value in both fundamental studies and clinical applications. This review focuses on the mechanisms, techniques, and app lications of iNSCs/iNPCs from a series of related studies, as well as further efforts in designing novel strategies using iNSC/iNPC technology and its potential applications in neurodegenerative diseases.

Keywords

induced neural stem cell; induced neural precursor cell; transdifferentiation; fundamental study; clinical application; neurodegenerative disease

[SpringerLink]