Current Issue Table of Contents: 15 November, 2025, Volume 41, Issue 11
About the Cover
Cerebral edema is a threatening complication of ischemic stroke. In this issue, Zhang et al. demonstrate that the combination of Salvianolic acid B and ginsenoside Rg1 (SalB/Rg1) alleviates cerebral edema related to the regulation of the glymphatic system (GS). The cover art creatively depicts this concept: At the center of the image lies the brain. On its left, a red vessel represents the cerebral artery; on its right, a blue vessel represents the cerebral vein. The perivascular spaces surrounding both arteries and veins are filled with light blue fluid, symbolizing the glymphatic system. Cerebrospinal fluid flows inward along the perivascular spaces of arteries, while interstitial fluid drains outward along the venous perivascular spaces. The unobstructed circulation of these inflow and outflow pathways is essential for maintaining normal brain function. After a stroke, however, the two pathways appear to be “tied into a knot,” triggering the onset of cerebral edema. The left hand represents Salvianolic acid B derived from Salvia miltiorrhiza, and the right hand represents Ginsenoside Rg1 derived from Panax notoginseng. Acting together like a pair of deft hands, SalB and Rg1 work to untie the knot that obstructs cerebrospinal fluid inflow and interstitial fluid outflow, thereby restoring glymphatic circulation and alleviating cerebral edema. See pages 1909–1923. (Cover provided by Huanqi Tan).
Call for Papers: Special Issue on Zebrafish Models in Neuroscience Research
Guest Editor: Prof. Alan V. Kaluev
Special Issue Celebrating the 25th Anniversary of the Institute of Neuroscience, CAS
Ting Lv1 · Yefei Li1 · Fei Dong1 · Shumin Duan2
Cenglin Xu1 · Yi Wang1 · Zhong Chen1
Mid-Infrared Light Exhibits Tissue-Specific Transmittance and Modulates Neural Signal Conduction Along Axons
Xi Liu1 · Zhuoyi Wang1
· Zhi Qiao2 · Yujie Xiao3 ·
Hui Guo4
· Yousheng Shu1
[SpringerLink]
Variations of Corticotropin-Releasing Factor Receptor 1α Contribute to the Blunted HPA Axis Responses to Hypoxia in Plateau Mammals
Jiafang Yang1,2,3 · Fangyuan Xia1,2 · Hao Jin2
· Chatoo Mahanand1,2 · Huiqi Lin4
· Yibin Cao5
· Jianghui Bian6
·
Dengbang Wei7
· Eviatar Nevo8
· Jizeng Du1,2 · Shumin Duan2,9 · Fang Guo2,10 · Yang Zhao4 · Xuequn Chen1,2
[SpringerLink]
Neural Circuit with Top-Down Inhibitory Feedback Outperforms Optimal Bayesian Integration in Multisensory Integration
Yelin Dong1,2 · Hongzhi You3
· Yuxiu Shao1
· Yong Gu4
·
KongFatt Wong‑Lin5
· Da‑Hui Wang1
[SpringerLink]
Lost in Space and Thought: Navigating the Cognitive Map in Alzheimer’s Disease
Bo Zhao1
· Shaojiong Zhou1
· Tao Wei1
· Jiahua Xu2
·
Chaofan Geng1
· Zhibin Wang1,3 · Yi Tang1,3,4
[SpringerLink]
Oligodendrocyte Egr2 Mediates the Beneficial Effect of Resocialization on the Social Ability of Socially Isolated Mice
Yanli Zhang1,2 · Sijia Chen1
· Shuying Zhang1
·
Yue Li1
· Yimiao Wang1
· Min Cao1
· Yuxi Jin1
·
Ze Wang1
· Shixin Ding1,3 · Ming Xiao1
[SpringerLink]
Correction to: Engineered Extracellular Vesicles Loaded with MiR‑100-5p Antagonist Selectively Target the Lesioned Region to Promote Recovery from Brain Damage
Yahong Cheng1
· Chengcheng Gai1
· Yijing Zhao1
· Tingting Li1
· Yan Song1
·
Qian Luo2
· Danqing Xin1
· Zige Jiang1
· Wenqiang Chen3
· Dexiang Liu2
·
Zhen Wang1
[SpringerLink]
Downregulation of UQCRC1 Expression Leads to Cognitive Decline by Disrupting the Cilia in the Dentate Gyrus
Jing Zhang1,2,4 · Tianyao Liu2
· Zonghong Long1
· Zuoxi Wu1
· Jing Luo2
· Fuhai Bai1
·
Lianyu Zhou2
· Hong Gong2
· Meifeng Gong2
· Hong Li1
· Xiaotang Fan2,3
[SpringerLink]
Hierarchical Replay of Multi-regional Sequential Spiking Associated with Working Memory
Ermeng Huang1
· Da Xu1
· Huangao Zhu1
· Zhaoqin Chen2,3 · Yulei Chen1,3 · Shujun Lei2,3 · Jiawei Liu1
·
Chengyu T. Li1,2,3 · Xiaoxing Zhang2,3
[SpringerLink]
A New Driver of Parkinson’s Disease: FAM171A2 Facilitates α-Synuclein Uptake and Spread
Qiuhan Wang1 · Tao Qiu1 · Yiying Hu1,2 ·
Tianbai Li1
[SpringerLink]
Synaptic Protein Lactylation: A Novel Mechanism Underlying Physical Exercise-mediated Stress Resilience
Can‑Yuan Zhang1 · Su‑Fen Wei1,2 · Xiong Cao1
[SpringerLink]
The Eyes are The Windows To The Soul: Pupillary Changes Reflect The Consolidation of New and Old Memories During Sleep
Wei‑Kun Su1 · Yan‑Jia Luo2 · Fangyuan Li1 · Hong Jiang2 · Jing Wang1 ·
Ya‑Dong Li1,3
[SpringerLink]
Threat-Driven Social Plasticity: Switch from Innate Attraction to Conditioned Preference
Hongyu Zuo1
· Jie Li1 · Xia Zhang1,2 · Bin Zhang1
[SpringerLink]
GPR37L1 in Spinal Astrocytes: A Potential Target for Neuropathic Pain Management
Jingyang Xu1
· Yufeng Chen1
· Lerong Chen1,2 ·
Boyi Liu1,3
[SpringerLink]
Imaging and Quantifying the Diversity of Native NMDA Receptors
Sophie Shi1 · David Stroebel1 · Laetitia Mony1 ·
Pierre Paoletti1
[SpringerLink]
Novel Strategies for Cognitive Enhancement via Noninvasive Neuromodulation
Hongwei Li1,2 · Kun Zhao2,3 · Yong Liu2,3,4
[SpringerLink]
The Astrocyte: A New Component of The Engram Regulates Memory Recall
Ru Li1,2 · Zilan Luo1,2 · Ding Zhong2,4 · Xia Deng2
·
Liang Gao1,2,3
[SpringerLink]
Cortical Dysplasia Beyond mTOR: Cellular Senescence Takes a Toll
Yixin Zhan1,2 · Jiping Zhou3 · Guoqing Zheng1,2 ·
Yang Zheng1,2
[SpringerLink]
Zona Incerta: A Bridge for Infant-Mother Interaction
Yawen Huang1
· Jun Wang2,3,4,5 · Na Liu2,3,4,5 ·
Han Xu2,3,4,5
[SpringerLink]
Mapping Fear-Related Neural Activity and Circuitry Changes Following Prophylactic Administration of (R,S)-Ketamine and (2S,6S)-Hydroxynorketamine
Minzhu Li1
· Li Cheng1
[SpringerLink]
“CATCH ME IF YOU CAN”: Unlocking the Hidden Key in Obesity Intervention via the Vagus-Jejunum Axis
Shuo Zhang1,2 · Lingyu Xu1
· Yila Ding1
· Cenglin Xu1
[SpringerLink]
Psilocybin and Obsessive-Compulsive Disorder: Exploring New Therapeutic Horizons
Longwei Yang1,2 · Haohong Li3,4 · Xiaohui Wang1,2,4
[SpringerLink]
Exploring the Therapeutic Potential of Psychedelics in Chronic Pain Management: A New Frontier in Medicine
Cong Lin1
· Xue Wang2
· Xiaohui Wang1,3
[SpringerLink]
Halting the Progression of Alzheimer’s Disease: Is the Goal in Sight?
Yu‑Juan Jia1,2 · Xuan‑Yue Wang3
· Jie Liu2
· Yan‑Jiang Wang4,5 ·
Colin L. Masters6 · Jun‑Hong Guo1
[SpringerLink]
The Current State and Future Outlook of PET Tracers for AMPA Receptors
Ling Li1
· Shenglin Wen1
· Ji Dai2,3,4,5
[SpringerLink]
Psychoactive Substances: Transforming the Paradigm for Treating Mental Health Disorders in the Post-Pandemic Era
Haojiang Zhai1,2 · Yibo Wang1 · Xiaohui Wang1,2
[SpringerLink]
Neurotensin Modulates Emotional Valence Assignment in the Basolateral Amygdala Through Neuromodulator Gain
Maimaitishalijiang Abudureheman1,2 · Yu‑Hao Xiao1,2 ·
Li‑Zang Zeng1,2 · Hong‑Yan Geng1,2
[SpringerLink]
Constructing A Theoretical Model to Bridge Neural Transition with a State Switch in Bipolar Disorder
Xiaonan Guo1
· Lizichen Chen2
· Jianbo Lai1,4 ·
Shaohua Hu1,3,4,5,6,7,8
[SpringerLink]
Liquid–Liquid Phase Separation within Dense-Core Vesicles in Sympathetic Adrenal Chromaffin Cells
Quanfeng Zhang1
· Zhaohan Lin1
· Xinyu Du1
·
Zhuan Zhou1,2,3
[SpringerLink]
The Claustrum Controls Motor Activity Through Anterior Cingulate Cortex Input and Local Circuit Synchronization in a Preparatory Manner
Zi‑Qi Kou1,2 · Chun‑Yan Chen1,2 · Mamatsali Abdurahman1,2 · Xu‑Chu Weng1,2 ·
Chun Hu1,2 · Hong‑Yan Geng1,2
[SpringerLink]
Photobiomodulation: A Potential Non-invasive Method to Alleviate Neurological Events Following COVID-19 Infection
Chongyun Wu1
· Timon Cheng‑Yi Liu1
· Rui Duan1
·
Luodan Yang1
[SpringerLink]
The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals
Yuncheng Zhu • Liangliang Chen • Haifeng Ji • Maomao Xi • Yiru Fang • Yi Li
[SpringerLink]
Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China
Academy of Cognitive Disorders of China (ACDC) • Yuliang Han • Jianjun Jia • Xia Li • Yang Lv • Xuan Sun • Shanshan Wang • Yongjun Wang • Zhiwen Wang • Jintao Zhang • Jiong Zhou & Yuying Zhou
[SpringerLink]
An Overview of the Expert Consensus on the Prevention and Treatment of Gaming Disorder in China (2019 Edition)
Yu-Tao Xiang • Yu Jin • Ling Zhang • Lu Li • Gabor S. Ungvari • Chee H. Ng • Min Zhao & Wei Hao
[SpringerLink]
Perspective on Etiology and Treatment of Bipolar Disorders in China: Clinical Implications and Future Directions
Zuowei Wang • Chen Jun • Keming Gao • Haichen Yang • Yiru Fang
[SpringerLink]
Standardized Operational Protocol for Human Brain Banking in China
Wenying Qiu • Hanlin Zhang • Aimin Bao • Keqing Zhu • Yue Huang • Xiaoxin Yan • Jing Zhang • Chunjiu Zhong • Yong Shen • Jiangning Zhou • Xiaoying Zheng • Liwei Zhang • Yousheng Shu • Beisha Tang • Zhenxin Zhang • Gang Wang • Ren Zhou • Bing Sun • Changlin Gong • Shumin Duan & Chao Ma
[SpringerLink]
Oxidative stress in Alzheimer's disease
Zhichun Chen, Chunjiu Zhong
[SpringerLink]
Emerging role of Toll-like receptors in the control of pain and itch
Tong Liu, Yong-Jing Gao and Ru-Rong Ji
[SpringerLink]
An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options OPEN ACCESS
Anne Masi • Marilena M. DeMayo • Nicholas Glozier • Adam J. Guastella
[SpringerLink]
Caspase-3 activation as a bifurcation point between plasticity and cell death
Shikha Snigdha, Erica D Smith, G Aleph Prieto, Carl W Cotman
[SpringerLink]
Behavioral animal models of depression
Hua-Cheng YAN, Xiong CAO, Manas Das, Xin-Hong ZHU, Tian-Ming GAO
[SpringerLink]
The glial scar in spinal cord injury and repair
Yi-Min Yuan, Cheng He
[SpringerLink]
Roles of the hippocampal formation in pain information processing
Ming-Gang LIU, Jun CHEN
[SpringerLink]
Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension
Jing-Jing Zhou • Hui-Jie Ma • Jian-Ying Shao • Hui-Lin Pan • De-Pei Li
[SpringerLink]
The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals
Yuncheng Zhu 1 • Liangliang Chen 2 • Haifeng Ji 2 • Maomao Xi 3 • Yiru Fang 1,5,6 • Yi Li 4
[SpringerLink]
An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options OPEN ACCESS
Anne Masi1 • Marilena M. DeMayo1 • Nicholas Glozier1 • Adam J. Guastella1
[SpringerLink]
Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases
Longzhu Liu • Ming Zhao • Xiaojiang Yu • Weijin Zang*
[SpringerLink]
Gene Editing to the Rescue: Reversal of Social Deficits Associated with MECP2 Duplication
Zi-Xian Yu 1,2,3 • Dan-Yang Wang 1,2,3 • Xiao-Hong Xu 1,3
[SpringerLink]
Regulation of Pain and Itch by TRP Channels
Carlene Moore1 • Rupali Gupta1 • Sven-Eric Jordt2 • Yong Chen1,* • Wolfgang B. Liedtke1,2,*
[SpringerLink]
Spinal Circuits Transmitting Mechanical Pain and Itch
Bo Duan1,* • Longzhen Cheng2,* • Qiufu Ma3,*
[SpringerLink]
Special Issue on Novel Insight into Glial Biology and Diseases
Issue editor: He Cheng
2023 Vol 39 Issue 3
[PDF]
[SpringerLink]
Special Issue on Pain and Itch
Guest Editor: Ru-Rong Ji
2022 Vol 38 Issue 4
[PDF]
[SpringerLink]
Special Issue: Purinergic Signaling in the Central Nervous System in Health and Disease
Guest Editor: Yong Tang, Peter Illes, and Guang-Yin Xu
2020 Vol 36 Issue 11
[PDF]
[SpringerLink]
Special Issue:Bipolar Disorders
Guest Editor:Yiru Fang
2019 Vol 35 Issue 4
[PDF]
[SpringerLink]
Special Issue: Neurotechniques
Guest Editor: Guo-Qiang Bi
2019 Vol 35 Issue 3
[PDF]
[SpringerLink]