Current Issue Table of Contents: 15 June, 2026, Volume 42, Issue 6
Impact Factor 5.8*
Journal Citation Reports
Q1 (2024 CLARIVATE
ANALYSTICS)
About the Cover
Hypothermia is widely recognized for its neuroprotective effects against cerebral hypoxic-ischemic injury, yet the developing brain remains vulnerable to white matter injury (WMI) during hypothermic hypoxia-ischemia, which can disrupt neurodevelopment and lead to long-term deficits. In this issue, Chen et al. demonstrate that microglial pyroptosis and subsequent interleukin 18 release drive mature oligodendrocyte death and axonal demyelination, ultimately causing WMI. Pharmacological inhibition of pyroptosis with disulfiram (DSF) alleviates WMI and preserves neurodevelopmental integrity. The cover is conceptualized around the theme of “the limitations of hypothermia and the protective power of pharmacotherapy”. The icy cavern encapsulates the hypothermic hypoxic-ischemic environment, visually emphasizing the paradox of hypothermia: while it offers neuroprotection, it also leaves the developing brain’s white matter—specifically the myelin sheaths—vulnerable to injury. Within this frigid landscape, the human brain is adorned with purple violets, which represent neurons, each wrapped in a delicate green layer symbolizing the myelin sheath—the primary target of damage in this pathological process. The blooming violets and intact green myelin illustrate how targeting microglial pyroptosis can restore neurodevelopmental balance, turning a state of myelin injury into one of resilience. See pages 1199–1217. (Cover provided by Dr. Xiaoping Tong and Dr. Zhongqun Zhu)
Call for Papers: Special Issue on Zebrafish Models in Neuroscience Research
Guest Editor: Prof. Alan V. Kaluev
Special Issue Celebrating the 25th Anniversary of the Institute of Neuroscience, CAS
Ting Lv1 · Yefei Li1 · Fei Dong1 · Shumin Duan2
Cenglin Xu1 · Yi Wang1 · Zhong Chen1
Redefining PHOX2B-Related Neurodevelopmental Disorders as Circuitopathies: A New Paradigm in Autonomic Network Medicine
Zixu Zhang1,2 · Shengru Hu1,2 · Yaxuan Chen1
· Ting He2
· Wei Xie2
·
Mingdao Mu1,2
[SpringerLink]
Vesicle3D: An Integrative Platform for 3D Segmentation and Analysis of Vesicles in Cryo-electron Tomograms
Zheng‑Yu Lv1,2,3 · Zhen‑Hang Lu2,3 · Shuo Liu3,4 · Pengcheng Zhou3,4 ·
Pak‑Ming Lau2,3 · Guo‑Qiang Bi1,2,3 · Chang‑Lu Tao2,3
[SpringerLink]
CNTN6 Modulates Slit-Robo Signaling in Cortical GABAergic Interneuron Migration
Yiliang Xu1,2 · Tian Zhao1,2 · Dan Zhao1,2 · Wei Zhang1
· Di Mu1
· Ailing Gui1
·
Junzhi Guo1,2 · Kazutada Watanabe3
· Zhi‑Cheng Xiao4,5 · Haihong Ye1,2
[SpringerLink]
The Role of Serotonergic System in Parkinson’s Disease-Related Pain
Yi‑Zhi Song1,2 · Yan‑Qin Shen1,2,3
[SpringerLink]
Environmental Factors Drive Neurodegenerative Diseases Through Glutamate Excitotoxicity: A Convergent Mechanistic Pathway
Yulu He1
· Tingting Yi1
· Meixin Min1
· Ke Xu1
· Huan Lin1
· Rong Xu2
· Dan Deng3
·
Xiaoping Xiao1
[SpringerLink]
Mitochondrial Transfer from Glia to Neurons: A Novel Protective Mechanism Against Peripheral Neuropathy
Xiao‑Wen Meng1,2 · Yong‑Jing Gao1
[SpringerLink]
The Roles of Tbx2 in Cochlear Development and Auditory Function
Xiang Li1 · Yurou Zhang1
· Zhenghong Bi1 ·
Renjie Chai1,2
[SpringerLink]
Measuring the Impacts of Urbanicity and Different Exposome Factors on Human Brain through Exposure Network Mapping
Na Luo1,2 · Zhengyi Yang1,2 · Ming Song1,2 · Shiqi Di1,2 · Congying Chu1
· Weiyang Shi1
· Weihua Yue3,4 ·
Yuyanan Zhang3,4 · Hao Yan3,4 · Xiao Zhang3,4 · Dai Zhang3,4 · Jing Sui5
· Vince Calhoun6
· Tianzi Jiang1,2,7,8
[SpringerLink]
Epigenetic Tuning of TSC: A Metabolic Master Switch for Human Neocortical Expansion
Jun‑Wei Cao1 · Yinghui Fu2
[SpringerLink]
Beyond the Seizure Onset Zone: Fast Ripples as Anchors for Precise Neurostimulation Therapy
Shuye Ying1
· Jialu Chen2
· Xukun Fan1
· Yi Wang1
·
Fan Fei1
[SpringerLink]
Mesolimbic Dopaminergic Encoding of Decision Value: Linking Phenotype-Specific Signals to Strategic Adaptation
Zhengyi Xu1
· Dadao An1
· Jingjia Liang1
·
Lingyan Zheng1
· Zhong Chen1
[SpringerLink]
Dorsal Column Nuclei at the Core of TENS: Circuit Principles and Outlook for Neuropathic Pain Therapy
Yi‑La Ding1
· Xue‑Qing Wu1
· Tian‑Xin Zhao1
·
Shi‑Yao Wang1
· Ceng‑Lin Xu1
· Bei Tan1 · Yu Du1
[SpringerLink]
Persistence of Proliferating Neural Progenitors in the Adult Human Hippocampus: New Evidence from snRNA-seq and Machine Learning Integration
Jun‑Wei Cao1 · Bing Lang2
[SpringerLink]
Astrocytes Control Norepinephrine Signaling in the Brain
Hai‑Yun Xiong1
· Peter Illes1,2 · Yong Tang1
[SpringerLink]
Subparafascicular Thalamic Nucleus: An Integration Center for Sexual Motivation and Physical Contact in Mating Behaviour
Siyuan Li1,2 · Xinrong Wang1,5 · Junqiang Zheng1,5 ·
Han Xu1,2,3,4,5
[SpringerLink]
Beyond the Glial Scar: Fibroblasts as Dynamic Coordinators of Neuroprotection and Neuroinflammation Post-Brain Injury
Xinjie Hong1,2 · Xiaoyong Qin2 · Lijun Hou1
[SpringerLink]
Putting the Brakes on Thirst: A Neural Circuit for Anticipatory Fluid Control
Boli Fu1,2 · Qiujie Shi1
· Qin Wang1
[SpringerLink]
Serpine2-Lrp1 and CD39-A3AR Intercellular Signalling Pathways: Novel Therapeutic Targets for Vascular Dementia
Xiao‑Feng Ran1
· Peter Illes1,2 · Yong Tang1
[SpringerLink]
Beyond Amyloid: Stem Cell Therapy Targets Neurodegeneration in Alzheimer’s Disease
Chenyue Li1
· Qiyi Hu1
· Qing Wang1,2,3 ·
Chunming Xie1,2,3
[SpringerLink]
The Thalamic Reticular Ultimatum: Carbamazepine’s Betrayal in Absence Epileptic Seizures
Xiongfeng Guo1
· Yuanzhi Yang1
· Junxiu Ye1
· Xiangyu Ma1
· Tong Liu1
·
Kai Zhong2 · Cenglin Xu1
[SpringerLink]
Targeting Microglial Connexin43 Hemichannels: A Novel Therapeutic Avenue for Alzheimer’s Disease
Chenju Yi1,2,3,4 · Yixun Su1
· Alexei Verkhratsky3,5,6,7,8
[SpringerLink]
Photobiomodulation and Addiction: Exploring Mechanisms, Therapeutic Potential, and Future Directions in Substance Use Disorders
Xiujiao Qin1
· Hongyuan Li2
· Huiying Zhao1 ·
Xiaohui Wang2,3,4
[SpringerLink]
IL-17 as a New Player in Neuroimmune Cross-Talk: Rewiring Behaviors Through Cytokine-Receptor Cartography
Jinmei Ye1
· Lan Yan2
· Zhibo Tang2
· Jiashuo Xu1
·
Jie Weng2 · Tifei Yuan2,3 · Daihui Peng1
[SpringerLink]
Preparatory Activity Indexes Motor Memory in the Motor Cortex
Xiao–Lin Shen1,2,3 · He–Xin Zhao1,2,3 ·
Yu–Hao Xiao1,2,3 · Yong–Xiang Wang1,4,5 ·
Li–Zhang Zeng2,3 · Hong–Yan Geng1,6
[SpringerLink]
Electrochemical Detection of Oxytocin: Challenges and Prospects
Jiao Zhang1
· Xiaojian Li2,3,4 · Ji Dai2,3,4
[SpringerLink]
Targeting Microglial Connexin43 Hemichannels: A Novel Therapeutic Avenue for Alzheimer’s Disease
Chenju Yi1,2,3,4 · Yixun Su1
· Alexei Verkhratsky3,5,6,7,8
[SpringerLink]
Psilocybin and Obsessive-Compulsive Disorder: Exploring New Therapeutic Horizons
Longwei Yang1,2 · Haohong Li3,4 · Xiaohui Wang1,2,4
[SpringerLink]
Exploring the Therapeutic Potential of Psychedelics in Chronic Pain Management: A New Frontier in Medicine
Cong Lin1
· Xue Wang2
· Xiaohui Wang1,3
[SpringerLink]
Halting the Progression of Alzheimer’s Disease: Is the Goal in Sight?
Yu‑Juan Jia1,2 · Xuan‑Yue Wang3
· Jie Liu2
· Yan‑Jiang Wang4,5 ·
Colin L. Masters6 · Jun‑Hong Guo1
[SpringerLink]
The Current State and Future Outlook of PET Tracers for AMPA Receptors
Ling Li1
· Shenglin Wen1
· Ji Dai2,3,4,5
[SpringerLink]
The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals
Yuncheng Zhu • Liangliang Chen • Haifeng Ji • Maomao Xi • Yiru Fang • Yi Li
[SpringerLink]
Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China
Academy of Cognitive Disorders of China (ACDC) • Yuliang Han • Jianjun Jia • Xia Li • Yang Lv • Xuan Sun • Shanshan Wang • Yongjun Wang • Zhiwen Wang • Jintao Zhang • Jiong Zhou & Yuying Zhou
[SpringerLink]
An Overview of the Expert Consensus on the Prevention and Treatment of Gaming Disorder in China (2019 Edition)
Yu-Tao Xiang • Yu Jin • Ling Zhang • Lu Li • Gabor S. Ungvari • Chee H. Ng • Min Zhao & Wei Hao
[SpringerLink]
Perspective on Etiology and Treatment of Bipolar Disorders in China: Clinical Implications and Future Directions
Zuowei Wang • Chen Jun • Keming Gao • Haichen Yang • Yiru Fang
[SpringerLink]
Standardized Operational Protocol for Human Brain Banking in China
Wenying Qiu • Hanlin Zhang • Aimin Bao • Keqing Zhu • Yue Huang • Xiaoxin Yan • Jing Zhang • Chunjiu Zhong • Yong Shen • Jiangning Zhou • Xiaoying Zheng • Liwei Zhang • Yousheng Shu • Beisha Tang • Zhenxin Zhang • Gang Wang • Ren Zhou • Bing Sun • Changlin Gong • Shumin Duan & Chao Ma
[SpringerLink]
Oxidative stress in Alzheimer's disease
Zhichun Chen, Chunjiu Zhong
[SpringerLink]
Emerging role of Toll-like receptors in the control of pain and itch
Tong Liu, Yong-Jing Gao and Ru-Rong Ji
[SpringerLink]
An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options OPEN ACCESS
Anne Masi • Marilena M. DeMayo • Nicholas Glozier • Adam J. Guastella
[SpringerLink]
Caspase-3 activation as a bifurcation point between plasticity and cell death
Shikha Snigdha, Erica D Smith, G Aleph Prieto, Carl W Cotman
[SpringerLink]
Behavioral animal models of depression
Hua-Cheng YAN, Xiong CAO, Manas Das, Xin-Hong ZHU, Tian-Ming GAO
[SpringerLink]
The glial scar in spinal cord injury and repair
Yi-Min Yuan, Cheng He
[SpringerLink]
Roles of the hippocampal formation in pain information processing
Ming-Gang LIU, Jun CHEN
[SpringerLink]
Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension
Jing-Jing Zhou • Hui-Jie Ma • Jian-Ying Shao • Hui-Lin Pan • De-Pei Li
[SpringerLink]
The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals
Yuncheng Zhu 1 • Liangliang Chen 2 • Haifeng Ji 2 • Maomao Xi 3 • Yiru Fang 1,5,6 • Yi Li 4
[SpringerLink]
An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options OPEN ACCESS
Anne Masi1 • Marilena M. DeMayo1 • Nicholas Glozier1 • Adam J. Guastella1
[SpringerLink]
Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases
Longzhu Liu • Ming Zhao • Xiaojiang Yu • Weijin Zang*
[SpringerLink]
Gene Editing to the Rescue: Reversal of Social Deficits Associated with MECP2 Duplication
Zi-Xian Yu 1,2,3 • Dan-Yang Wang 1,2,3 • Xiao-Hong Xu 1,3
[SpringerLink]
Regulation of Pain and Itch by TRP Channels
Carlene Moore1 • Rupali Gupta1 • Sven-Eric Jordt2 • Yong Chen1,* • Wolfgang B. Liedtke1,2,*
[SpringerLink]
Spinal Circuits Transmitting Mechanical Pain and Itch
Bo Duan1,* • Longzhen Cheng2,* • Qiufu Ma3,*
[SpringerLink]
Special Issue on Pain and Itch
Issue Editor: Ru-Rong Ji
2025 Vol 41 Issue 12
[PDF]
[SpringerLink]
Special Issue Celebrating the 25th Anniversary of the Institute of Neuroscience, CAS
Issue Editors: ting lv,Fei Dong,Shumin Duan,Yefei Li
2024 Vol 40 Issue 11
[PDF]
[SpringerLink]
Special Issue on Novel Mechanism, Drug Target and Therapy in Epilepsy
Issue Editor: Zhong Chen
2024 Vol 40 Issue 5
[PDF]
[SpringerLink]
Special Issue on Novel Insight into Glial Biology and Diseases
Issue editor: He Cheng
2023 Vol 39 Issue 3
[PDF]
[SpringerLink]
Special Issue on Pain and Itch
Guest Editor: Ru-Rong Ji
2022 Vol 38 Issue 4
[PDF]
[SpringerLink]
