Subcellular Structures in Native Hippocampal Synapses Revealed by Cryo-electron Tomography
Chong‑Li Tian1,2 · Lei Qi1,3 · Zhen‑Hang Lu1,2 · Shuo Liu2,4 · Min‑Ling Gu1,2 · Wen‑Lan Huang2 ·
Yi‑Tong Yan1,2 · Yun‑Tao Liu5,6 · Jing Wu7 · Peiyi Wang7,8 · Z. Hong Zhou5,6 · Guo‑Qiang Bi1,2,3 ·
Pak‑Ming Lau1,2,3 · Chang‑Lu Tao1,2,4
2026,42(4):729–743 [
Abstract] [
SpringerLink]
[PDF]
HSF-1 Regulates Autophagy to Govern Motor Function and Facilitate Toxic Protein Clearance in a C. elegans Model of Amyotrophic Lateral Sclerosis
Hui Xu1 · Yaping Shao1
· Jun Zhang1
· Yang Ni1
· Guowang Xu2
· Cong Liu3,4 ·
Yi Liang5
· Weidong Le1,6
2026,42(4):744–764 [
Abstract] [
SpringerLink]
[PDF]
Physical Activity and Depressive Mood Share the Structural Connectivity Between Motor and Reward Networks
Shiqi Di1,2,3 · Na Luo1,2 · Weiyang Shi1,2 · Zhengyi Yang1,2 · Jing Sui4 · Rongtao Jiang5
· Yue Cui2,3 ·
Zongchang Du1,2,3 · Jiaqi Zhang1,2,3 · Yawei Ma1,2,6 · Haiyan Wang1,2 · Congying Chu1,2 · Yuejia Zhong1,2,3 ·
Wen Li1,2 · Yuheng Lu1,2,3 · Hao Yan7,8 · Jinmin Liao7,8 · Dai Zhang7,8,9 · Vince Calhoun10 · Ming Song1,2 ·
Tianzi Jiang1,2,3,11
2026,42(4):765–780 [
Abstract] [
SpringerLink]
[PDF]
Hippocampal Oligodendrocytes Regulate Mossy Fiber Development Involved in Epileptic Responses
Chunxia Jiang1,2 · Yunan Hu1
· Feng Zhang2
·
Mengsheng Qiu1
· Xiaofeng Zhao1
2026,42(4):781–794 [
Abstract] [
SpringerLink]
[PDF]
Temporoparietal Junction Selectively Mediates Social Projection in Mentalizing
Shaohan Jiang1,2 · Sidong Wang1 ·
Xiaohong Wan1
2026,42(4):795–810 [
Abstract] [
SpringerLink]
[PDF]
Microglial-Derived Cholesterol 25-Hydroxylase Promotes Epileptic Seizure and Neuroinflammation Mediated by NLRP3 Inflammasome and Lipid Metabolism
Haifeng Zhang1 · Tiantian Su1
· Xiaoke Wu2
·
Mengmeng Shi3
2026,42(4):811–826 [
Abstract] [
SpringerLink]
[PDF]
Dysregulation of the BRD2-FGF17 Signal Pathway Induces Abnormal Forebrain Development Associated with Schizophrenia
Xiao Yu1 · Jiacheng Du1
· Chenger Zhou1
· Yongheng Huang1,2 · Huijuan Li1
·
Bruce M. Cohen3
· Sangmi Chung4
· Zhicheng Shao1
2026,42(4):827–841 [
Abstract] [
SpringerLink]
[PDF]
Cellular Diversity Underpins Cortical Organization and Disease Vulnerability in the Human Brain
Yafeng Zhan1,2 · Cirong Liu1,2
2026,42(4):842–854 [
Abstract] [
SpringerLink]
[PDF]
Exploring Empathic Responses to Others’ Positive and Negative Experiences: Insights from Empathy Subprocesses
Xiao Wu1,2 · Xue‑Jing Lu1,2 · Li‑Bo Zhang1,2 ·
Si‑Rui Huo3
· Ya‑Zhuo Kong1,2 · Li Hu1,2
2026,42(4):855–871 [
Abstract] [
SpringerLink]
[PDF]
Circadian Rhythm Disorder-Related Dysfunctions are Exacerbated by Aging and Ameliorated by Time-Restricted Feeding
Fengjiao Huo1
· Qing Liu1
· Shuaishuai Zhang1
· Xiaorui Liu1
· Shuyao Lv1
· Meili Zhao1
· Yue Liu1
· Xiaoqi Zhu1
·
Ce Huang1
· Shengyu Feng1
· Hao Wang1
· Siling Xu1
· Junyan Shen1
· Jiaming Gao1
· Tingting Su2
· Yating Wu2
·
Ruichan Jiang2
· Jian‑Kang Zhu3
· Hailiang Liu1,2,3
2026,42(4):872–896 [
Abstract] [
SpringerLink]
[PDF]
Research Progress on the Biological Function and Homeostatic Disruption of Microglia in the Pathogenesis of Major Depressive Disorder
Shuqi Kong1,2,3 · Zhuoyue Huang1,2,3 · Yiru Fang2,3,4
2026,42(4):897–912 [
Abstract] [
SpringerLink]
[PDF]
The Hypothesis of Myelinodegeneration as an Initial Risk of Neuropathic Pain
Jun Chen1,2 · Shuangchan Wu1
2026,42(4):913–925 [
Abstract] [
SpringerLink]
[PDF]
Sexual Dimorphism of Dendritic Spine Plasticity in the Cortex of Adolescent Mice
Fujian Qi1
· Yanli Ran2
· Guodong Zhu1
· Wancong Ding1
· Xing Gao1
· Junru Liu1
·
Muhammad Tariq Hafeez1
· Huatai Xu3
· Shengxiang Zhang1
2026,42(4):926–930 [
Abstract] [
SpringerLink]
[PDF]
Comparison of Freeze-drying and Gradient Dehydration Treatment on X-ray Imaging for Three-dimensional Reconstruction of Early Human Embryonic Brain Samples
Yangqianbo Yao1
· Wenjie Hao2
· Shengju Wu1
· Qizhi He3 · Tiqiao Xiao2 ·
Zhijun Zhang1
2026,42(4):931–936 [
Abstract] [
SpringerLink]
[PDF]
Mesolimbic Dopaminergic Encoding of Decision Value: Linking Phenotype-Specific Signals to Strategic Adaptation
Zhengyi Xu1
· Dadao An1
· Jingjia Liang1
·
Lingyan Zheng1
· Zhong Chen1
2026,42(4):937–940 [
Abstract] [
SpringerLink]
[PDF]
Dorsal Column Nuclei at the Core of TENS: Circuit Principles and Outlook for Neuropathic Pain Therapy
Yi‑La Ding1
· Xue‑Qing Wu1
· Tian‑Xin Zhao1
·
Shi‑Yao Wang1
· Ceng‑Lin Xu1
· Bei Tan1 · Yu Du1
2026,42(4):941–944 [
Abstract] [
SpringerLink]
[PDF]
Synapses are fundamental units of neural circuits, and their efficiency and plasticity stem from the precise yet heterogeneous organization of organelles and molecular complexes. Tian et al. employ state-of-the-art cryo-ET to reveal the nanoscale architectures of intact hippocampal synapses in culture. The cover image features a 3D rendering of the cryo-ET reconstruction of a representative excitatory synapse, highlighting major components: plasma membrane (brown), endoplasmic reticulum and endosomes (yellow), mitochondria (bright green), microtubules (gray), ribosomes (grey‑pink), actin filaments (red), synaptic cleft molecules (pink), postsynaptic density (green), dense core vesicles (purple), dense granules (blue), empty clathrin cages (light-purple), and synaptic vesicles (light-green). This work provides a molecular view of the brain's communication units in their native context. See pages 729–743. (Cover designed by Chong-Li Tian, Shuo Liu, and Chang-Lu Tao)
