Oligodendroglial Mutant Huntingtin Contributes to Neuroinflammation in Huntington’s Disease Mice
Xinhui Li1
· Gongke Zhou1
· Shuying Xu1
· Tianqi Yang1
· Shurui Yin1
· Sitong Yang1
·
Yi Wu1
· Xinqi Zhou1
· Su Yang1
· Huichun Tong1,3 · Xiao‑Jiang Li1,2 · Shihua Li1
2026,42(7):1441–1458 [
Abstract] [
SpringerLink]
[PDF]
Mid-Infrared Light Exhibits Tissue-Specific Transmittance and Modulates Neural Signal Conduction Along Axons
Xi Liu1 · Zhuoyi Wang1
· Zhi Qiao2 · Yujie Xiao3 ·
Hui Guo4
· Yousheng Shu1
2026,42(7):1459–1472 [
Abstract] [
SpringerLink]
[PDF]
Unveiling a Novel Mechanism in Noise-Induced Hearing Loss: Oxeiptosis-Mediated Regulated Cell Death of Cochlear Hair Cell
Xinyu Zhang1
· Meihao Qi1
· Peng Zhang1
· Zejun Gao1
· Ziqi Wu1
· Wenyue Wang1
·
Runqin Yang1
· Xiaogang An1
· Fei Lu1
· Renfeng Wang1
· Qingwen Zhu1,2 ·
Dingjun Zha1
2026,42(7):1473–1491 [
Abstract] [
SpringerLink]
[PDF]
MSC-sEV Promote Regeneration of Cochlear Spiral Ganglion Neurons and Myelin Sheaths in 3D Culture System
Yunyou You1,2,3 · Anning Chen1,2,3 · Jiaxi Qu1,2,3 · Yiman Guo4
· Jing Pan1,2,3 ·
Taolue Yu1,2,3 · Fan Shu1,2,3 · Jie Tang1,2,3,5,6 · Hongzheng Zhang1,2,3
2026,42(7):1492–1506 [
Abstract] [
SpringerLink]
[PDF]
Aperiodic Brain Activity Modulates Corticospinal Excitability
Jingna Jin1,2 · Xin Wang1,2 · Xinyu Zhao1,2 ·
He Wang1,2 · Ying Li1,2 · Zhipeng Liu1,2 ·
Tao Yin1,2
2026,42(7):1507–1520 [
Abstract] [
SpringerLink]
[PDF]
Tissue-Resident Macrophage PIEZO1 Transduces Mechanical Stress into Inflammatory Pain in Acute Gout
Tianyi Shen1,2 · Ting Wang1,2 · Liyan Wu1,2 · Zihan Wang1,2 · Liqin Gan3
· Yubin Luo4
· Cong Liu5
·
Yang Xu6
· De‑An Guo2,3 · Qirui Bi3
· Wanying Wu2,3 · Lvyi Chen7
· Yi Chang8
· Jing Feng1,2
2026,42(7):1521–1535 [
Abstract] [
SpringerLink]
[PDF]
N-myristoyl Transferase Maintains Type II Neuroblasts through Notch Signaling in Drosophila
Sifan Gong1 · Shuliu Zhang1 · Xu Yan1
· Wenting Gong1 · Qingxia Zhou1 ·
Xiaojing Yang1 · Kun Yang2 · Menglong Rui1 · Su Wang1,2,3
2026,42(7):1536–1550 [
Abstract] [
SpringerLink]
[PDF]
IL-33 Regulates the Phenotypic Transformation of Reactive Astrocytes via PENK-ERK/MAPK Pathway in Parkinson’s Disease
Yi Qu1,2 · Zhijuan Mao1
· Danlei Wang1
·
Ke An1
· Haoheng Yu1
· Qixiong Qin3
· Jingyi Li1
·
Yongjie Xiong1
· Zhe Min1
· Zheng Xue1
2026,42(7):1551–1568 [
Abstract] [
SpringerLink]
[PDF]
A Non-spinal Neural Circuit for Transmitting Information of Bladder Conditions
Zhenxiang Zhu1,2,3,4 · Zhuang Liu6
· Zan Wang1,4 · Guangfu Cui2,3 · Mei‑Yu Shi7,8 · Kunzhang Lin2,3 · Yuxiang Qiu9
·
Tengxiao Si1,4 · Peng Chen2,3 · Qing Liu2,3 · Guo‑Qiang Bi2,3,7,8 · Jie Wang6
· Pengjie Wen2,3 · Fuqiang Xu1,2,3,4,5
2026,42(7):1569–1584 [
Abstract] [
SpringerLink]
[PDF]
Variations of Corticotropin-Releasing Factor Receptor 1α Contribute to the Blunted HPA Axis Responses to Hypoxia in Plateau Mammals
Jiafang Yang1,2,3 · Fangyuan Xia1,2 · Hao Jin2
· Chatoo Mahanand1,2 · Huiqi Lin4
· Yibin Cao5
· Jianghui Bian6
·
Dengbang Wei7
· Eviatar Nevo8
· Jizeng Du1,2 · Shumin Duan2,9 · Fang Guo2,10 · Yang Zhao4 · Xuequn Chen1,2
2026,42(7):1585–1598 [
Abstract] [
SpringerLink]
[PDF]
Reactive OPCs in CNS Injury: From Functional Diversity to Therapeutic Translation
Shengnan Wang1
· Hong Liu1
· Jiali Li1
· Yimin Yuan1,2,3 · Ziwei Dai1
· Zhida Lan1,3 ·
Chao Huang1,3 · Xiaojie Wei1
· Cheng He1
· Zhida Su1 · Shangyao Qin1
2026,42(7):1599–1616 [
Abstract] [
SpringerLink]
[PDF]
Role Shift of Glial Cells from Physiology to Pathology in Alzheimer’s Disease: The Regulatory Impact of Exercise
Runze Liu1
· Qianting Deng1
· Li Gong2
·
Luodan Yang1
2026,42(7):1617–1649 [
Abstract] [
SpringerLink]
[PDF]
Life Cycle and Circadian Rhythms in Central Resident Immunity and Neuropsychiatric Pathology
Zhixin Lim1,2,3,12 · Ha Linh Nguyen1,2,3,12 · Yuanyuan Zeng4
· Qigngyue Qu5
· Yan Le5
· Ming Sun1,2,3,6,12 ·
Xiaoyu Wang1,2,3,12 · Hong Zhu4,8,10 · Yuchen Qian6,12 · Saboor Saeed1,2,3,12 · Huaizhi Wang1,2,3,12 ·
Dazhong Rong2,7,12 · Yueming Wang2,7,12 · Xuhong Zhang1,2,3,8,9,12 · Shaohua Hu1,2,3,8,9,10,11,12,13
2026,42(7):1650–1674 [
Abstract] [
SpringerLink]
[PDF]
Autonomic Gating of Ripple Mode Selection at Sleep Onset
Mariana Toricelli1
· Sergio Tufik1,2 ·
Monica Levy Andersen1,2
2026,42(7):1675–1678 [
Abstract] [
SpringerLink]
[PDF]
Cholesterol in Myelin: Supply Routes, Pathological Consequences, Biophysical Governance, and Future Frontiers
Xinyu Zhu1,2,3 · Fan Zhang1
· Jian Wang4
·
Guannan Wang4
· Jiajia Wang1,5
2026,42(7):1679–1683 [
Abstract] [
SpringerLink]
[PDF]
Base Editing Offers New Hope for SCN8A-Related Epilepsy: A Precision Genetic Cure in Sight
Yuanzhi Yang1
· Cenglin Xu1 · Lijuan He2
2026,42(7):1684–1686 [
Abstract] [
SpringerLink]
[PDF]
An Immune-Brain Signaling Mediates Sickness-Induced Social Withdrawal
Yawen Huang1,2,3 · Junqiang Zheng2,3,4,5 · Han Xu2,3,4,5,6
2026,42(7):1687–1690 [
Abstract] [
SpringerLink]
[PDF]
Although neuronal autonomous toxicity is considered the primary driver in the pathogenesis of Huntington’s disease, accumulating evidence suggests that oligodendrocyte-mediated white matter injury represents an early pathological event that cannot be overlooked. Li et al. demonstrated that exclusive expression of mutant huntingtin (mHTT) in oligodendrocytes is sufficient to induce robust activation of pro-inflammatory glial cells and the release of various inflammatory cytokines in the striatum and corpus callosum, raising the possibility that targeting non-neuronal mHTT toxicity may offer a novel therapeutic strategy. On the cover, the brain is depicted as a magical sea, where oligodendrocytes expressing mHTT act as the storm center, like a giant whale spouting water, disrupting the surrounding microenvironment and triggering pro-inflammatory changes in nearby astrocytes and microglia. These reactive glial cells then release inflammatory mediators, represented as red substances emanating from disturbed fish. See pages 1441–1458. (Cover designed by Mingliang Fan and Shihua Li)
